Cancers in systemic sclerosis : risk factors, impact on survival and literature review.
CONCLUSION: The history of renal scleroderma crisis and the positivity of anti-topoisomerase I antibodies were associated with an increased risk of cancer in SSc patients in this monocentric study. PMID: 31255252 [PubMed - as supplied by publisher]
Publication date: Available online 30 June 2020Source: Artificial Intelligence in MedicineAuthor(s): Danqing Hu, Shaolei Li, Zhengxing Huang, Nan Wu, Xudong Lu
Authors: Koczwara B PMID: 32596806 [PubMed - as supplied by publisher]
Using laser excitation, expression microdissection (xMD) can selectively heat cancer cells targeted via immunohistochemical staining ...
Authors: Stevenson RB PMID: 32593344 [PubMed - in process]
CONCLUSION: Traditional techniques, like radiotherapy (RT) show decent results, although they cannot spare 100% the healthy tissues neighboring with the cancer ones. Targeted therapies, such as proton and photodynamic therapy (PT and PDT, respectively) present adequate outcomes, even though each one has its own drawbacks. In order to overcome these limitations, the combination of therapeutic modalities has been proposed and has already been showing promising results. At the same time, the recent advances in nanotechnology in the form of nanoparticles enhance cancer therapy, making multimodal treatments worthy of exploring ...
Conclusion: No statistically significant radiation associations were observed among 114,270 nuclear weapons test participants followed for up to 65 y. The 95% confidence limits were narrow and exclude mortality risks per unit dose that are two to four times those reported in other investigations. Significantly elevated SMRs were seen for mesothelioma and asbestosis, attributed to asbestos exposure aboard ships. PMID: 32602389 [PubMed - as supplied by publisher]
Publication date: Available online 30 June 2020Source: Molecular and Cellular ProbesAuthor(s): Shuo Chen, Yan Wang, Mingyue Xu, Lin Zhang, Yinan Su, Boxue Wang, Xipeng Zhang
Authors: Yang CL, Serra-Roma A, Gualandi M, Bodmer N, Niggli F, Schulte JH, Bode PK, Shakhova O Abstract Neuroblastoma (NB) is the most common cancer in infants and it accounts for six percent of all pediatric malignancies. There are several hypotheses proposed on the origins of NB. While there is little genetic evidence to support this, the prevailing model is that NB originates from neural crest stem cells (NCSCs). Utilizing in vivo mouse models, we demonstrate that targeting MYCN oncogene to NCSCs causes perinatal lethality. During sympathoadrenal (SA) lineage development, SOX transcriptional factors drive the t...
CONCLUSIONS: GNRI is significantly associated with OS and CSS in elderly gastric cancer patients and is an independent predictor of OS. It is a simple, cost-effective, and promising nutritional index for predicting OS in elderly patients. PMID: 32595832 [PubMed]
CONCLUSIONS: We identified a 2 gene Random Forest model of BIRC3 and CD300LG that predicted lymph node involvement in a validation cohort. This validated model, following testing in additional cohorts, could be used to create a reverse transcription-quantitative polymerase chain reaction (RT-qPCR) tool that would be useful for helping to identify patients with LN involvement in resource-limited settings. PMID: 32595829 [PubMed]
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