Proteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer.

CONCLUSION: Quantitative proteomic analysis elucidated the molecular targets associated with the production of SGU and provides insights into the role of the MD. The underlying molecular mechanisms need to be further dissected. PMID: 31249449 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

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Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small intestinal ulcers, which are accompanied by a mucosal invasion of bacteria and subsequent activation of immune cells. Galectin-3 (Gal3), an endogenous lectin, has anti-microbial and pro-inflammatory functions. In the small intestine, since Gal3 is highly expressed in epithelial cells constitutively and macrop...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Oral ulcers are common problems seen by dentists but pediatricians also see them. Usually families have are concerned because they are painful and acute. Ulcers are sometime noticed by the physician and not the family as in the case of herpangina or hand-foot and mouth disease. Chronic or recurrent ulcerations present less commonly and therefore it may be more difficult to determine their etiology. Many of the systemic disease causes of oral ulcers are overall infrequent and/or not common in the pediatric age range. Ulcers can be classified in several ways but acute ulcers are usually painful and last less tha...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract Gastric ulcer is a frequent gastrointestinal tract (GIT) disorder that affects about 10% of the world population. Drug candidates that can provide high efficacy and low toxicity are needed value for the prevention and treatment of gastric ulcers. The present study aimed to assess the protective effect of mesalazine against ethanol-induced gastric mucosal injury in rats. The rats were divided into five groups, normal, ethanolic, standard (recipient ranitidine 50 mg/kg), experimental groups 1, 2 (receive mesalazine at doses of 50 and 100, respectively). The protective effect of mesalazine was evaluated by...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Abstract Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs (NSAIDs), stress conditions, and alcohol, resulting in an inflammatory condition in the gastric mucosa. The aim of this study was to explore the protective effects of modafinil on gastric erosions induced by indomethacin, water-immersion stress, and alcohol in rats and to evaluate the role of nitric oxide (NO) pathway. Animals were allocated to the three experimental models of gastric ulcer - indomethacin (30 mg/kg PO), water-immersion stress, and ethanol (5 ml/kg PO). Induction of gastric ulc...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
The objectives of our study were to determine the different metabolites in the Cyperus conglomeratus Rottb. methanol extract, and to assess its in vivo gastroprotective effect in ethanol-induced gastric ulcer model in rats. Serum levels of galactin-3 and TNF-α were employed as biochemical markers. To pinpoint for active agents, comprehensive metabolites profiling of extract via UPLC-qTOF-MS/MS was employed. A total of 77 chromatographic peaks were detected, of which 70 were annotated. The detected metabolites were categorized into phenolic acids and their derivatives, flavonoids, stilbenes, aurones, quinones, ter...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractGastric ulcer is a very common illness that adversely affects a significant number of people all over the globe. Phytochemical investigation ofP. glabra leaf alcohol extract (PGLE) resulted in the isolation and Characterization of a new nature compound, quercetin-3- O- α -L-rhamnosyl-(1′''-6′')-(4′'-O -acetyl)-β -D-galactoside (4), in addition to seven known compounds. They are ferulic acid (1),p- coumaric acid (2), quercetin 3-O- α-L-rhamnoside-3 ′-O- β-D-glucoside (3), quercetin-3- O-α -L-rhamnosyl-(1 ′''-6′')-(4′'-O -acetyl)- β –Dga...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 7 September 2020Source: The American Journal of SurgeryAuthor(s): Clara Zhu, Jeremy Badach, Andrew Lin, Natasha Mathur, Sean McHugh, Benjamin Saracco, Amanda Adams, John Gaughan, Umur Atabek, Francis R. Spitz, Young K. Hong
Source: The American Journal of Surgery - Category: Surgery Source Type: research
CONCLUSIONS: F-AOH inhibits ethanol-induced gastric mucosal damage, provides a theoretical basis for galangal in the treatment of other causes of GU, and promotes the application of galanga in the treatment of GU. PMID: 32871094 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
DiscussionMMF is well known for common GI side-effects such as nausea, diarrhea, vomiting, ulcers, abdominal pain and rarely gastrointestinal bleeding. Few studies reported 3 to 8% incidence of ulcer perforation and GI bleeding within 6 months. Risk of gastroduodenal erosions is nearly 1.83 times for MMF, with the highest lesions associated with MMF-tacrolimus-corticosteroid combination treatment as seen in our patient. Hypothesis is that GI tract is vulnerable because of dependence of enterocytes on de novo synthesis of purines, which is disrupted by MMF. Typically, upper GI mucosal injuries of mucosal irritation leading ...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
In conclusion, the peripheral NK cell level may be a diagnostic and prognostic marker for patients with GC. PMID: 32855731 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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