The ‘CASTLE’ tumour: An extremely rare presentation of a thyroid malignancy. A case report

Publication date: Available online 30 June 2019Source: Annals of Medicine and SurgeryAuthor(s): Diana Mellisa Dualim, Loo Guo Hou, Shahrun Niza Abdullah Suhaimi, Nani Harlina Md Latar, Rohaizak Muhammad, Nordashima Abd ShukorAbstractThyroid carcinoma showing thymic-like differentiation (CASTLE) is a rare malignancy of the thyroid gland, and it accounts for 0.1–0.15 % of all thyroid cancers. As the name suggests, it has a histological and immunophenotypic resemblance to thymic carcinoma. Preoperative diagnosis of CASTLE can be difficult as its clinical manifestations, and histological characteristic resembles other aggressive and advanced thyroid carcinomas. It is essential to distinguish CASTLE from other aggressive neoplasms as the former has a more favourable prognosis. Immunohistochemical staining with CD5 can help to differentiate thyroid CASTLE from other aggressive thyroid neoplasms.Due to the rarity of this disease, there is no clear definitive treatment strategy. Surgical resection of CASTLE is usually attempted initially. Nodal involvement and extrathyroidal extension are shown to be the main prognostic factors that influenced the survival of patients. Therefore, complete resection of the tumour is vital to reduce local recurrence rates and to improve the chance of long-term survival. Radiotherapy (RT) for CASTLE is an effective treatment. Curative surgery followed by adjuvant RT should be considered in cases with extrathyroidal extension and nodal metastases. ...
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research

Related Links:

ConclusionsPhysicians should be aware of the possibility of the emergence of primary malignancies in patients with a history of papillary thyroid carcinoma, especially lung cancer as it is a common site of papillary thyroid carcinoma metastases. Using appropriate diagnostic evaluations in order to choose the best therapeutic option is of utmost importance.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Oleanolic acid (OA) is a naturally occurring triterpenoid that possesses antitumor activity against several tumor cell lines. However, the potential mechanism underlying OA-induced thyroid carcinoma cell death is poorly understood. We investigated the biological functions of OA by performing migration, invasion, colony formation, and apoptosis assays on SW579 cells. Forkhead box A1 (FOXA1) expression was used to predict poor prognosis in patients with thyroid carcinoma among the TCGA samples from the UALCAN and gene expression profiling interactive analysis databases. Western blot was used to detect protein expression leve...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Papers Source Type: research
Thyroid, Ahead of Print.
Source: Thyroid - Category: Endocrinology Authors: Source Type: research
We describe a case of successful in vitro fertilization pregnancy and delivery after a fertility-sparing laparoscopic operation in a patient with papillary thyroid carcinoma arising from a mature cystic teratoma. PMID: 31401818 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
Conclusions: In progressive HCC, several treatment options outside or inside clinical trials are available. WGS of metastatic tumors might direct the timing of therapy. Unlike other cancers, the absence of RAS variants seems to provide insufficient justification of single-agent panitumumab administration in HCC cases harboring a near-homozygous genome.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This study aims to characterize dysregulated immune-associated and cancer-associated genes in three PTC subtypes to explore how the interplay between cancer and immune processes causes differential prognosis. RNA-sequencing data from The Cancer Genome Atlas (TCGA) were used to identify dysregulated genes in each variant. The dysregulation profiles of the subtypes were compared using functional pathways clustering and correlations to relevant clinical variables, genomic alterations, and microRNA regulation. We discovered that the dysregulation profiles of classical PTC (CPTC) and the tall cell variant (TCPTC) are similar an...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Ho AS, Luu M, Zalt C, Morris LGT, Chen I, Melany M, Ali N, Patio C, Chen Y, Mallen-St Clair J, Braunstein G, Sacks W, Zumsteg ZS Abstract Background Active surveillance is established as an alternative to surgery for papillary thyroid microcarcinomas, but inclusion criteria and mortality risk for pursuing a nonsurgical approach have not been clearly defined. To gauge the feasibility of expanding active surveillance thresholds, we investigated the effects of increasing size and age on disease-specific survival in a large nonoperative thyroid cancer cohort, compared against a matched group of surgical patien...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: In this study, we report the occurrence of functional MEK1 mutations in papillary thyroid cancer. All mutations are in-frame deletion in exon 3 of MEK1, representing another mechanism of activation of the MAPK pathway in papillary carcinomas with predominantly follicular growth pattern. PMID: 31407636 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
AbstractGastrointestinal stromal tumours (GIST) are the most common gastrointestinal mesenchymal tumours of the gastrointestinal tract. They are diagnosed by the expression of markers like CD 117, CD 34, DOG-1 and PDGFRA. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. Few studies have shown the high incidence of a second malignancy including papillary thyroid cancer (PTC) in known patients of GIST. Literature review on pathogenesis of GIST and PTC showed that PTC targeting Protein Kinase C theta (PKC θ) plays role in both PTC and GIST. Further studies have ...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
In this largest SNP risk association study for medullary thyroid carcinoma (MTC), a significant protective risk association ofCDKN1A Ser31Arg SNP with MTC was shown for the first time. Expanded meta ‐analysis including our cohort identified significant risk association with four RET SNPs, not observed in previous meta‐analysis. AbstractBackgroundMedullary thyroid carcinoma (MTC) is a rare subtype of thyroid cancer. Other than gain ‐of‐functionRET mutations, no other genetic, lifestyle or environmental risk associations have been established for MTC. Several case ‐control studies and meta‐analysis have examined ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | General Medicine | Thyroid | Thyroid Cancer | Tracheostomy