Antimicrobial Peptides: An Approach to Combat Resilient Infections.

CONCLUSION: Antimicrobial peptides (AMPs) are short, cationic peptides evolved in a wide range of living organisms and serve as the essential part of host innate immunity. For humans, these effector molecules either can directly kill the foreign microbes or modulate the host immune systems so that human body could make some resistance against the microbial infections. In this review, we discuss their history, structural classifications, modes of action, and explain their biological roles as anti-infective agents. We also scrutinize their clinical potentiality, current limitations in various developmental stages and strategies to overcome for their successful clinical applications. PMID: 31250760 [PubMed - as supplied by publisher]
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research