Cytotoxic KLRG1 expressing lymphocytes invade portal tracts in primary biliary cholangitis.

Conclusion: Highly cytotoxic KLRG1+ lymphocytes have invaded PBC liver portal areas. Liver KLRG1 gene expression and the abundance of KLRG1+ lymphocytes are positively correlated with disease biomarkers used as clinical trial outcome measures (liver transplantation and serum alkaline phosphatase), suggesting the targeting of KLRG1+ lymphocytes as a rational approach for PBC therapeutic drug development.
PMID: 31255417 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - June 25, 2019 Category: Allergy & Immunology Authors: Li Y, Li B, You Z, Zhang J, Wei Y, Li Y, Chen Y, Huang B, Wang Q, Miao Q, Peng Y, Fang J, Gershwin ME, Tang R, Greenberg SA, Ma X Tags: J Autoimmun Source Type: research