Genotypic analysis of XRCC4 and susceptibility to cervical cancer.

Genotypic analysis of XRCC4 and susceptibility to cervical cancer. Br J Biomed Sci. 2019 Jun 28; Authors: Gupta MK, Kushwah AS, Singh R, Banerjee M Abstract Background: XRCC4 encodes a DNA repair protein which maintains the genome stability by repairing double-strand breaks by the error-prone method. Defects in the protein-encoding gene leads to impairment of DNA repair process and accumulation of DNA damage, a hallmark of cancer development. We hypothesised that variants in XRCC4 are linked in cervical cancer has been carried out for the prediction of disease susceptibility. Material &Methods: Genotyping of XRCC4 variants viz. intron3 DIP (rs28360071), intron7 DIP (rs28360017), G-1394T(rs6869366) and G-652T (rs2075685) was carried out in 246 women with cervical cancer cases and 246 control women. Results: There were several links to cervical cancer: intron3 DIP (rs28360071) II genotype (p=0.002) and I allele (odds ratio [95% CI] 0.69 [0.54-0.809](p=0.004), intron7 DIP (rs28360017) II genotype (p=0.003) and I allele (odds ratio 0.68 [0.53-0.88] (p=0.004), and G-652T (rs2075685) genotype (p=0.044) and the T allele (odds ratio 1.35 (1.03-1.77)(p=0.032). In combining data into haploviews, the DDGG allele combination had an odds ratio of 0.12 (0.04-0.39)(p
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
In conclusion, the addition of triapine to cisplatin-radiotherapy improved the rate of metabolic complete response in patients with advanced-stage uterine cervix or vaginal cancers without significant toxicity. A phase III trial adequately powered to evaluate progression-free and overall survival is underway (NCT02466971).
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOur data provides experimental evidence on the contribution of PARP-1 inhibition in enhancing the cytotoxicity of CDDP in cervical cancer cells. We also present novel findings on the suppression of β-catenin and its downstream signaling components by PARP-1 inhibitor. #: 5μM of CDDP was used both alone and in combination with PJ34; ##: A gradient of CDDP from 0-15μM was used to evaluate the combined effect of PJ34 and CDDP on IC50 value of CDDP. p: *
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673. Oncol Rep. 2019 Sep 13;: Authors: Cao P, Wang Y, Lv Y, Jiang N, Zhong L, Ma X, Xiao X, Ding D, Gu J, Lin L, Li S Abstract Poly(ADP‑ribose) polymerase (PARP) inhibitors have little effect on homologous recombination repair (HRR)‑proficient tumor types, such as cervical cancer. In addition to catalytic activity, the PARP inhibitor, BMN673, traps PARP1 on damaged DNA and induces cytotoxic effects. The aim of the present study was to evaluate the therapeutic effect of PI3K inhi...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
High-risk human papillomaviruses (HR-HPVs) promote cervical cancer as well as a subset of anogenital and head and neck cancers. Due to their limited coding capacity, HPVs hijack the host cell’s DNA replication and repair machineries to replicate their own genomes. How this host–pathogen interaction contributes to genomic instability is unknown....
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulat...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
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Source: Journal of Pelvic Medicine and Surgery - Category: Surgery Tags: Original Articles Source Type: research
DN604, containing a functional dicarboxylato ligand as carboplatin analogue, was significantly studied to explore its potency of antitumour activity. In vitro and in vivo experimental evidence indicated that DN604 exhibited superior antitumor activity than present platinum(II)-based agents in cervix squamous carcinoma SiHa cancer cells. Moreover, DN604 showed negligible toxic effects in vivo as confirmed as Pt accumulation and body weights of mice. Mechanistic studies have shown that DN604 suppressed CK2-mediated MRN complex to improve its antitumor efficacy by promoting DNA double-strand breaks repair. Furthermore, DN604 ...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Papers Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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