A historical cohort of temporal lobe surgery for medically refractory epilepsy: a systematic review and meta-analysis to guide future nonrandomized controlled trial studies.

CONCLUSIONS: The overall rate of seizure freedom for temporal lobe surgery is approximately 70% for medically refractory epilepsy. The small sample size of the RCT cohort underscores the need to move beyond standard RCTs for epilepsy surgery. This historical seizure-freedom rate may serve as a useful benchmark to guide future study designs for new surgical treatments for refractory TLE. PMID: 31252393 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31252393?dopt=Abstract

Source: Journal of Neurosurgery - June 27, 2019 Category: Neurosurgery Authors: Lee AT, Burke JF, Chunduru P, Molinaro AM, Knowlton R, Chang EF Tags: J Neurosurg Source Type: research