Dose to water versus dose to medium from cavity theory applied to small animal irradiation with kilovolt x-rays.

Dose to water versus dose to medium from cavity theory applied to small animal irradiation with kilovolt x-rays. Phys Med Biol. 2019 Jun 28;: Authors: Vaniqui A, Walters B, Fonseca GP, Verhaegen F Abstract Dose reporting is a matter of concern in the preclinical field as the different dose descriptors dose-to-water-in-medium (<i>D</i><sub>wm</sub>) and dose-to-medium-in-medium (<i>D</i><sub>mm</sub>) coexist. For kV photons differences between both quantities are expected to be amplified due to photon energy absorption coefficients differences for different media, and could represent a limiting factor for accurate translation of preclinical research into clinical trials. The main goal of this study was to analyse the relationship between <i>D</i><sub>mm</sub> and <i>D</i><sub>wm</sub> for preclinical kV irradiation, using different flavours of the intermediate cavity theory (ICT). 
 Irradiations of mathematical phantoms and a mouse CT scan, both with different voxel sizes and materials were investigated. A modified version of the Monte Carlo code DOSXYZnrc was used to derive &...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research