Task-based image quality assessment in radiation therapy: initial characterization and demonstration with computer-simulation study.

Task-based image quality assessment in radiation therapy: initial characterization and demonstration with computer-simulation study. Phys Med Biol. 2019 Jun 28;: Authors: Dolly S, Lou Y, Anastasio MA, Li H Abstract In the majority of current radiation therapy (RT) applications, image quality is still assessed subjectively or by utilizing physical measures. A novel theory that applies objective task-based image quality assessment in radiation therapy (IQA-in-RT) was recently proposed, in which the area under the therapeutic operating characteristic curve (AUTOC) was employed as the figure-of-merit (FOM) 
 for evaluating RT effectiveness. Although theoretically more appealing than conventional subjective or physical measures, a comprehensive implementation and evaluation of this novel task-based IQA-in-RT theory is required for its further application in improving clinical RT. In this work, a practical and modular IQA-in-RT framework is presented for implementing this theory for the assessment of imaging components on the basis of RT treatment outcomes. Computer-simulation studies are conducted to demonstrate the feasibility and utility of the proposed IQA-in-RT framework in optimizing X-ray CT pre-treatment imaging, including the optimization of CT imaging dose and image reconstruction parameters. The potential advantages of optimizing imaging components in the RT workflow by use of the AUTOC as the FOM are also compared against those of other phy...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
AbstractPurpose of ReviewTo review the latest information about the interactions between cancer and cerebrovascular disease.Recent FindingsAdditional data support the finding that both ischemic and hemorrhagic stroke are important complications of cancer or its treatment. Reperfusion therapy is being given successfully to patients with stroke complicating cancer.SummaryHemorrhagic stroke may occur with metastatic disease to the brain, coagulopathies from cancer, in particular leukemia, or as complications of chemotherapy. Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) is a standard of care for medically inoperable patients. Our aim was to compare Common Terminology Criteria for Adverse Events (CTCAE) thoracic grade 3 or higher adverse events (AEs) of 30 Gy in one fraction (arm 1) vs. 60 Gy in 3 fractions (arm 2).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
ConclusionsMultiscale approach ’s predictive capabilities are based on the fundamental scientific knowledge. Their strength is in relation to actual physical, chemical, and biological processes that take place following the ions incidence on tissue. This makes the approach flexible and versatile to include various conditions, s uch as the degree of aeration or the presence of sensitizing nanoparticles, related to particular cases. The ideas for how the MSA can contribute to an improved optimization of therapy planning are summarized in the review.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research
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Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 25 June 2019Source: Practical Radiation OncologyAuthor(s): Sarah Z. Hazell, Russell K. Hales, William T. Hrinivich, Kristy Ford, Ken Kang-Hsin Wang, Todd R. McNutt, Peijin Han, Lori J. Anderson, Adam C. Ferro, Joseph Moore, Khinh Ranh VoongAbstractPurposeNonhomogeneous dose optimization (NHDO) is exploited in stereotactic body radiation therapy (SBRT) to increase dose delivery to the tumor and allow rapid dose falloff to surrounding normal tissues. We investigate changes in plan quality when NHDO is applied to inverse-planned conventionally fractionated radiation therapy (CF-RT) plans in ...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research
Condition:   Cancer Intervention:   Radiation: Radical Image-Guided Radiotherapy Sponsors:   CCTU- Cancer Theme;   University of Cambridge;   Microsoft Research Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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