Creatinine and cystatin C-based evaluation of renal function among obese subjects in Benin City, Nigeria.
Creatinine and cystatin C-based evaluation of renal function among obese subjects in Benin City, Nigeria. Saudi J Kidney Dis Transpl. 2019 May-Jun;30(3):648-654 Authors: Alaje AK, Adedeji TA, Adedoyin AR, Idogun SE Abstract Obesity is a recognized worldwide epidemic with increasing prevalence in developing nations. Studies have shown that obesity is an independent risk factor for the development of chronic kidney disease (CKD) besides its link with diabetes mellitus and hypertension. We evaluated the renal status of obese patients using both the established [creatinine (Cr)] and new (cystatin C) markers of renal function. This was a cross-sectional study. Fifty-nine consenting adults attending the clinic for routine medical checks were recruited for this study. They were divided into obese and non-obese based on their body mass index. Serum from specimens collected were assayed for Cr and cystatin C. CKD equations were used to estimate glomerular filtration rate based on Cr (eGFR-Cr), cystatin C (GFR-Cystatin), and Cr/cystatin C (GFRCr/cystatin) while modification of diet in renal disease equation was also used to eGFR-Cr. The eGFR results generated were compared in assessing renal function. The obese participants and the controls were age-matched (50.6 ± 9.7 vs. 50.7 ± 7.8 years, P = 0.2). The obese participants had a significantly higher serum cystatin C (1.3 ± 0.7 vs. 0.9 ± 0.4 mg/L, P
Contributors : Kristoffer G Rigbolt ; Helene ÆgidiusSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologically validated diet-induced obese (DIO) NASH mice compared to chow-fed controls. Bulk RNA-sequencing and proteomics showed a clear distinction between phenotypes and...
Authors: Bolek EC, Kaya Akca U, Sari A, Sag E, Demir S, Kilic L, Sener YZ, Aykan HH, Kaya EB, Bilginer Y, Akdogan A, Kiraz S, Karadag O, Ozen S Abstract OBJECTIVES: Takayasu's arteritis (TAK) is a chronic vasculitis, affecting predominantly the aorta and/or its major branches. The aim of this study was to compare the differences between childhood and adult onset TAK. METHODS: We retrospectively evaluated 179 TAK patients followed between August 2005 and July 2019. Demographic characteristics, laboratory features, disease activity, echocardiographic data at diagnosis and treatment regimens in the disease course ...
Publication date: Available online 18 September 2020Source: American Journal of Kidney DiseasesAuthor(s): Charalampos Loutradis, Charles J. Ferro, Pantelis Sarafidis
Authors: Rosenberg CR, Abazari A, Chou TY, Weissbart SB Abstract A retrospective chart review examined adult patients with herpes simplex (HSV) and zoster (HZO) keratitis at a single institution. Patients who suffered a poor outcome (defined as visually significant corneal scarring, neurotrophic keratitis, secondary glaucoma, or requiring corneal surgery) were identified and each outcome type was analyzed in relation to age, sex, diabetes mellitus, immunosuppression, and a prior history of ≥2 ocular procedures. Advanced age, diabetes mellitus, and a prior history of ≥2 ocular procedures may be risk factors fo...
CONCLUSIONS: In the first 10 years of life, from prospectively collected serial growth measurements, we found no evidence of impaired childhood growth before CD and CDA development as identified through early and periodic screening. PMID: 32941083 [PubMed - as supplied by publisher]
Publication date: Available online 18 September 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Sayon Roy, Dongjoon Kim
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Publication date: Available online 17 September 2020Source: Pregnancy HypertensionAuthor(s): Ljiljana Mirkovic, Ivan Tulic, Sanja Stankovic, Ivan Soldatovic
In this study, forty-male Wistar albino rats were randomly divided into four groups (n = 10). Group A received normal saline. Group B received glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Groups C and D were pretreated with Luteolin 100 and 200 mg/kg for 7 days, and thereafter administered Glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Administration of glycerol significantly increased systolic blood pressure, diastolic blood pressure and mean arterial pressure. Renal protein carbonyl and xanthine oxidase increased significantly while significant reduction in ...
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