POEMS Syndrome: Indian Experience From a Tertiary-Care Institute

We report a retrospective analysis of 49 cases from a single tertiary-care center in New Delhi, India, including 10 patients who underwent hematopoietic stem-cell transplantation. Clinical features, responses, and outcomes were similar to the Western and Eastern literature, though with some unique features.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research

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Conclusions: Salvage chemotherapy (often with rituximab and radiotherapy), followed by HDT and stem cell transplantation, appears to be the standard real-world treatment for rrPMBCL. However, large prospective and retrospective studies are warranted to improve our knowledge of real-world treatment patterns. PMID: 31951774 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Güemes-Villahoz N, Burgos-Blasco B, Moreno-Morillo FJ, Troyano-Rivas JA PMID: 31948686 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Publication date: Available online 18 January 2020Source: Stem Cell ResearchAuthor(s): Seerat Elahi, G. Aaron Holling, Aimee B. Stablewski, Scott H. OlejniczakAbstractThe RNA binding protein ARS2 is highly expressed in hematopoietic progenitor populations and is required for adult hematopoiesis. Recent molecular studies found that ARS2 coordinates interactions between nascent RNA polymerase II transcripts and downstream RNA processing machineries, yet how such interactions influence hematopoiesis remains largely unknown. Techniques to differentiate embryonic stem cells (ESC) to hematopoietic progenitor cells (HPC) and matu...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
In this study, we established a three-dimensional (3D) differentiation model of neurospheres, which produce unique neuronal clusters, termed NeuroCore (NC). NC formation was initiated by the aggregation of young neurons. Upon maturation of the neurons and the establishment of radial glia-like structures, the initial organization of the NCs transformed into a glomeruli-like arrangement of cortical neurons. These neurons expressed multiple markers of upper and deep cortical neurons. Taken together, we propose that NSCs in vitro maintain some aspects of their original in vivo tissue-organizing properties, providing an alterna...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 17 January 2020Source: Stem Cell ResearchAuthor(s): Kathrin Haake, Tim Wüstefeld, Sylvia Merkert, Doreen Lüttge, Gudrun Göhring, Bernd Auber, Ulrich Baumann, Nico LachmannAbstractChronic mucocutaneous candidiasis (CMC) is a disease that is characterized by susceptibility to chronic or recurrent infections with Candida spp. due to mutations affecting mainly the IL17 signaling of T-Cells. The most common etiologies of CMC are gain-of-function (GOF) mutations in the STAT1 gene. In this paper we report the generation of a hiPSC line from a patient suffering from CMC due to a he...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 17 January 2020Source: Stem Cell ResearchAuthor(s): Jing Wang, Yazhou Cui, Kaixuan Xing, Jing Luan, Jinxiang HanAbstractA human induced pluripotent stem cell (iPSC) line (SMBCi002-A) was established from amniocytes (amniotic fluid cells, AFDCs) from a 16-week-old female fetus with clubfoot. Reprogramming and enhancing factors OCT4, SOX2, KLF4, MYC, LIN28 and EBNA1 were delivered using a nonintegrative strategy based on episomal plasmids. Validation assays indicated that this iPSC line has full pluripotency, differentiation potential and genetic stability. Currently, the etiology and mecha...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
CONCLUSION: FMT seems to be a promising and safe therapy in the management of UC. Further research, with larger cohorts, will be needed to confirm this and to determine the optimal FMT procedure. PMID: 31950808 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
In this study we sought to identify mechanisms of disease development by comparing the immune tumor microenvironment (iTME) of patients with POEMS syndrome to that of patients with MGUS.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
ConclusionThis retrospective analysis provides important information on the clinical characteristics of POEMS syndrome in Indian patients, which will help the clinician’s decision-making process.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
ConclusionThe data presented here would be key to the clinician’s decision-making process particularly in the Indian context.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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