Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

AbstractPurpose of ReviewThe main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration.Recent FindingsPluripotent stem cell –based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications.SummaryThis review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research