Boswellic Extracts and 11-Keto-ß-Boswellic Acids prevent Type 1 and Type 2 Diabetes Mellitus by suppressing the Expression of Proinflammatory Cytokines

ConclusionsPreclinical and clinical data suggest that BE and/or 11-keto-ß-boswellic acids by inhibiting the expression of proinflammatory cytokines from immune-competent cells, may prevent insulitis and insulin resistance in type 1 and type 2 diabetes, respectively, and therefore may be an option in the treatment/prevention of type 1 and type 2 diabetes. It is hypothesized that molecularly, BE and 11-keto-ß-boswellic acids act via interference with the IκB kinase/Nuclear Transcription Factor-κB (IKK/NF-κB) signaling pathway through inhibition of the phosphorylation activity of IKK. However, further investigations and well-designed clinical studies are required.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research