Four new cucurbitane-type triterpenes from Momordica charantia L. with their cytotoxic activities and protective effects on H 2 O 2 -damaged pancreatic cells

AbstractFour new cucurbitane-type triterpenes were isolated from the fruit ofMomordica charantia L. The structures of the new compounds were identified based on HR-ESI-MS and 1D- and 2D-NMR spectroscopic methods. The cytotoxicity of the isolated compounds was evaluated using three human cancer cell lines, HeLa, Caco2, and U87. Compound3 exhibited significant cytotoxic activity against HeLa cells with an IC50 value of 11.18  μM. Additionally, the cytoprotective activity of these compounds was determined in vitro against H2O2-induced pancreatic injury. The results revealed that all the compounds obtained possess cytoprotective effects against H2O2-induced injury in MIN6 β-cells at a concentration of 10 μM.

Source: Journal of Natural Medicines - June 28, 2019 Category: Drugs & Pharmacology Source Type: research