Genetics Home Reference: PDGFRB-associated chronic eosinophilic leukemia

Genetics Home Reference: PDGFRB-associated chronic eosinophilic leukemia
Source: NLM General Announcements - Category: Databases & Libraries Source Type: news

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Chronic graft-versus host disease (cGvHD) is a major complication of allogeneic hematopoietic stem cell transplantation. Standard treatment mainly consists of corticosteroids but is limited by a high percentage of steroid-refractory cases. Alloreactive T cells are a major driver of the disease, infiltrating target organs such as the liver. However, global ablation of T cells interferes with the graft-versus-leukemia effect and bears the risk of increased infections. An increased use of glycolysis has been shown to drive T cell activation and its inhibition can blunt T cell effector functions.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 242 Source Type: research
CD19 directed chimeric antigen receptor T cell (CART19) therapy has resulted in unprecedented clinical outcomes. However, its success in chronic lymphocytic leukemia (CLL) has been modest to date. An increasing body of evidence indicates that impaired CART cell fitness is the predominant mechanism of the relative dysfunction in CLL. The immunosuppressive microenvironment in CLL is well known and may be related to the abundance of circulating extracellular vesicles (EVs) bearing immunomodulatory properties.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 3 Source Type: research
Allogeneic stem cell transplantation (SCT) is potentially curative therapy for patients with MDS. Prior studies have shown no overall-survival (OS) advantage of any conditioning regimen over the others. Reduced-intensity conditioning (RIC) is usually associated with lower non-relapse mortality (NRM) compared to myeloablative conditioning (MAC), however, relapse rates are higher, resulting in similar OS. Fludarabine and treosulfan (FT) is a reduced-toxicity regimen with intense anti leukemia activity in patients with myeloid malignancies.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 43 Source Type: research
We present a retrospective analysis of several reduced intensity conditioning (RIC) regimens. Methods This was a retrospective study with an aim of comparing survival outcomes in patients with myeloid disorders [acute myeloid leukemia (AML), chronic myeloid leukemia (CML), myelodysplastic disorders (MDS), and myeloproliferative neoplasms (MPN)] who underwent HCT at our institution between the years 2008-2017.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 235 Source Type: research
Adolescent and young adult (AYA) acute leukemia patients have inferior outcomes in comparison to their younger counterparts, related to higher risk disease and increased toxicity (Hochberg J, et al., BJH, 2013). AYA recipient age ( ≥13 years) vs children (ages 2-12 years) has been associated with increased acute and chronic graft versus host disease (GVHD) in matched sibling donor SCT (Qayed M, et al., BBMT, 2017).
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 269 Source Type: research
Abstract Chronic lymphocytic leukemia is a common disease in Western countries and has heterogeneous clinical behavior. The relevance of the genetic basis of the disease has come to the forefront recently, with genome-wide studies that have provided a comprehensive view of structural variants, somatic mutations, and different layers of epigenetic changes. The mutational landscape is characterized by relatively common copy number alterations, a few mutated genes occurring in 10-15% of cases, and a large number of genes mutated in a small number of cases. The epigenomic profile has revealed a marked reprogramming of...
Source: Annual Review of Pathology - Category: Pathology Authors: Tags: Annu Rev Pathol Source Type: research
Leukemia, Published online: 24 January 2020; doi:10.1038/s41375-020-0708-1Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells
Source: Leukemia - Category: Hematology Authors: Source Type: research
Conditions:   Chronic Myelomonocytic Leukemia;   Myelodysplastic Syndrome;   Recurrent Chronic Myelomonocytic Leukemia;   Recurrent Myelodysplastic Syndrome;   Refractory Chronic Myelomonocytic Leukemia;   Refractory Myelodysplastic Syndrome Interventions:   Drug: Azacitidine;   Biological: Canakinumab Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Hansson L, Jarosova M, Ghia P, Poddighe P, Espinet B, Pospisilova S, Tam C, Ysebaert L, Nguyen-Khac F, Oscier D, Haferlach C, Schoumans J, Stevens-Kroef M, Eldering E, Stamatopoulos K, Rosenquist R, Strefford JC, Mellink C, Kater AP Abstract Complex karyotype (CK) identified by chromosome-banding analysis (CBA) has shown prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high-resolution genome-wide detection of copy-number alterations (CNAs) and could therefore be well equipped to detect the presence of a CK. Current knowledge on genomic arrays in CLL is based on outcomes of single center...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
PMID: 31974193 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
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