Mayo Clinic Minute: Improved treatments for head and neck cancer

About 70% of cancers in the oropharynx, which includes the tonsils, soft palate and base of the tongue, are linked to the HPV virus, according to the Centers for Disease Control and Prevention. So it's important to talk to your health care provider about the HPV vaccine, especially if you are 26 years old or [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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ConclusionsSalivary SLPI was not associated with OPC risk but was associated with higher odds of an incomplete treatment response.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
ConclusionsStandardized diagnostic workup followed by ND and risk-factor adapted therapy improves survival of NSCCUP-P.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
r J Abstract Some head and neck cancers are caused by human papillomavirus (HPV). As HPV vaccination can prevent infection, an estimation of which HPV types have an active viral oncogene transcription in what proportion of tumors might allow estimation of the proportion of head &neck cancers preventable by HPV vaccination. We used all RNA sequencing data from primary tumors of head and neck squamous cell carcinomas from the Cancer Genome Atlas (n = 500 patients). We analysed 3.7 terabyte of sequencing data with the bioinformatics pipeline ViraPipe. Paired end reads were quality filtered using the ori...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
CONCLUSION: Transoral robotic base of tongue mucosectomy (or lingual tonsillectomy) is a promising technique that offers a high yield of positive identification for the primary tumour. It is well tolerated with minimal associated morbidity. Our findings are comparable with those in the current literature. PMID: 32347742 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
ConclusionsIn our cohort, vitamin D serum levels did not seem to play a role in HPV-positive OPC, OC, or OPC in general. Further larger studies are needed to evaluate the potential association between vitamin D deficiency and head and neck cancer risk.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Santosh K. Ghosh1*, Thomas S. McCormick1,2 and Aaron Weinberg1* 1Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States 2Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States Human beta-defensins (hBDs, −1, 2, 3) are a family of epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges. In addition to their antimicrobial activities, they possess other functions; e.g., cell activation, proliferation, regulation of cytokine/chemokine production, migration, diffe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instruments i...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Head and neck cancers represent approximately 3.8% of cancers globally where greater than 95% of these are squamous cell carcinoma (HNSCC) [1,2]. HNSCC has been typically associated with tobacco and alcohol use but the human papillomavirus (HPV) has emerged as a discrete aetiology, particularly in the oropharyngeal areas of the tonsils and base of the tongue. Oropharyngeal squamous cell carcinoma (OPSCC) is recognised as a subset among HNSCC with a strong association to HPV oncogenesis where prevalence rates are as high as 80% [3].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Review Article Source Type: research
This study reports outcomes of TORS procedures performed with the da Vinci Xi platform including perioperative adverse events, functional outcomes, and short-term local control. A retrospective review of TORS performed with the da Vinci Xi platform is undertaken. Twenty-two consecutive TORS cases with the Xi platform are reviewed. Procedures performed include radical tonsillectomy, base of tongue resection, and lingual tonsillectomy. Two bleeding events occurred (9% of cases), both of intermediate severity as per Mayo criteria. Three procedures resulted in positive margin status, early in the case series, and two were clea...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
CONCLUSIONS: Panendoscopy including tonsillectomy should not be omitted in the work up. SIGNIFICANCE: We demonstrate a steady frequency of HN-CUP and constant success in identifying the primary site. Detection of a primary later in the follow up did not impact the survival. PMID: 30016889 [PubMed - as supplied by publisher]
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
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