Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation

ConclusionThe olfactory neuroepithelium employs multiple mechanisms to maintain epithelial homeostasis. Our findings provide evidence that in a mouse model of BMI1 deletion, the overall integrity and function of the olfactory neuroepithelium are not compromised, despite increased neuronal turnover, reflecting a remarkable reparative capacity to sustain a critical sensory system.

https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.22366?af=R

Source: International Forum of Allergy and Rhinology - June 27, 2019 Category: Allergy & Immunology Authors: Rhea Choi, Sarah Kurtenbach, Bradley J. Goldstein Tags: ORIGINAL ARTICLE Source Type: research