Recent Advancement and Clinical Implications of 18FDG-PET in Parkinson ’s Disease, Atypical Parkinsonisms, and Other Movement Disorders
This article reviews FDG-PET studies in Parkinson ’s disease (PD), atypical parkinsonism (AP), Huntington’s disease (HD), and dystonia.Recent FindingsThe metabolic pattern of PD, disease progression, non-motor symptoms such as fatigue, depression, apathy, impulse control disorders, and cognitive impairment, and the risk of progression to dementia have been identified with FDG-PET studies. In prodromal PD, the REM sleep behavior disorder-related covariance pattern has been described. In AP, FDG-PET studies have demonstrated to be superior to D2/D3 SPECT in differentiating PD from AP. The metabolic patterns of HD and dystonia have also been described.SummaryFDG-PET studies are an excellent tool to identify patterns of brain metabolism.
Authors: Winer JP, Forgeard M, Cardeli E, Issa O, Ellis BH Abstract The process of resettlement in a new country and culture is commonly one of intense stress. Somali immigrants and refugees living in North America represent a large ethnocultural group navigating the complexities of forced displacement and resettlement. Despite the immense resilience exhibited by Somali communities in resettlement, the behavioral health needs of these communities require effective and culturally appropriate psychological assessment tools that can be used across service and research sectors. Given this need, we sought to examine the...
CONCLUSIONS: Our preliminary research suggests that Behavioral Activation modified to address social connectedness in homebound older adults improves both social isolation and loneliness. This intervention has potential for scalability in programs that already serve homebound older adults. Further research is needed to solidify the clinical evidence base, replicate training and supervision procedures, and demonstrate the sustainability of Brief Behavioral Activation for Improving Social Connectedness for homebound and other older adults. PMID: 32980253 [PubMed - as supplied by publisher]
CONCLUSIONS: Our findings demonstrate little occurrence of olfactory hallucinations but that when they occur, they are experienced as relatively unpleasant in AD patients. Our findings also demonstrate a relationship between olfactory hallucinations and psychiatric characteristics (i.e., depression) in AD. PMID: 32981566 [PubMed - as supplied by publisher]
CONCLUSION: Completion of hospital-based psychological counseling was the most highly influential factor determining the outcome of the collaboration between the emergency department and community-based mental healthcare center in the management of individuals who had attempted suicide. Completion of hospital-based psychological counseling is expected to help reduce the risk of repeat suicide attempts. PMID: 32989930 [PubMed - in process]
Clinicians hope that sex will increasingly be considered in clinical trial design and in treating cardiovascular disease comorbid with dementia and depression.Medscape Medical News
Publication date: Available online 30 September 2020Source: Neurophysiologie CliniqueAuthor(s): Jean-Paul Nguyen, Alcira Suarez, Catherine Malineau, Véronique Dixneuf, Gilles Mazaltarine, Philippe Damier
CONCLUSIONS: Vanillin seems to offer protective properties against 6-OHDA lesion via preserving striatal dopamine levels. PMID: 32986633 [PubMed - as supplied by publisher]
REM sleep behavior disorder in athletes may signal chronic traumatic encephalopathy and suggests brainstem pathologies may be to blame.Medscape Medical News
Children of women who used cannabis while they knew they were pregnant may be at greater risk of symptoms of mental illness than children of women who did not use cannabis during pregnancy, according to areport inJAMA Psychiatry. For instance, youth who were exposed to cannabis in the womb were more likely to report more psychotic-like experiences, as well as problems with aggressive behavior, depression, and anxiety than those without such exposure.“[P]regnant women, and even those contemplating pregnancy, should be discouraged from using any cannabis by health care professionals, dispensaries, and others,” wr...
This study underscores the importance of chronic stimulation in the modulation of sensorimotor integration and proprioception. The authors considered two possible mechanisms underlying SAI modulation by STN DBS. High-frequency DBS of the STN might normalize synchronization between basal ganglia structures, which might restore the ability of thalamocortical relay cells to respond to depolarizing inputs involved in sensorimotor integration (Brown et al., 2001; Rubin and Terman, 2004). Alternatively, STN DBS might have a direct effect on cortical structures through antidromic stimulation of the cortico-subthalamic pathway. I...