Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep.

CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that pharmacokinetic parameters for PTX and M-I varied in a dose-dependent linear manner in healthy sheep. Further studies are warranted to determine the therapeutic threshold and optimal dosage for PTX in sheep.
PMID: 31246127 [PubMed - in process]

Source: American Journal of Veterinary Research - June 29, 2019 Category: Veterinary Research Authors: Corum O, Corum DD, Atik O, Er A, Uney K Tags: Am J Vet Res Source Type: research