The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization.

In this study, we examined the role of IL-38, a member of IL-1 family, in mediating inflammation-induced angiogenesis. The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-a, IL-6, IL-8 and IL-1b was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells was reduced by IL-38 treatment in vitro. The data indicate that IL-38 modulates inflammation-induced angiogenesis. PMID: 31244436 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research