Plinia cauliflora (Mart.) Kausel: toxicological assays, biological activities, and elemental analysis of organic compounds.

Plinia cauliflora (Mart.) Kausel: toxicological assays, biological activities, and elemental analysis of organic compounds. Nat Prod Res. 2019 Jun 26;:1-5 Authors: Mendonça de Assis P, Cypriano Dutra R, Amarante CBD, Afonso Miranda Chaves MDG, Moreira CPS, Brandão MAF, Raposo NRB Abstract Jaboticaba, Plinia cauliflora (Mart.) Kausel, is a Brazilian berry traditionally used in folk medicine as treatment for some health conditions. Phenolic compounds such as flavonoids and anthocyanins have previously been detected in the fruit. This current study aimed to evaluate the toxicological effects of jaboticaba peel extract (JPE) on Artemia salina, L929, and MDA-MB-231 cell lines. Besides, JPE antioxidant, acetylcholinesterase, and antifungal activities, and elemental analysis CHNS were also tested. JPE had moderate toxicity (LD50 = 360.92 μg mL-1) on A. salina, non-toxic effect on L929 cell line, and decreased the viability of cancer cell line MDA at 1,000 µg mL-1 and 500 µg mL-1 concentrations. The antioxidant activity toward 2,2-diphenyl-1-picrylhydrazyl (DPPH) performed IC50 = 37.45 ± 0.17 µg mL-1, whereas 45.7% of acetylcholinesterase activity was inhibited. By its elemental composition, JPE is an alternative food supplement and dermocosmetic component. Antifungal potential toward Candida strains was not observed. PMID: 31242771 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research