Respiratory Sound Based Classification of Chronic Obstructive Pulmonary Disease: a Risk Stratification Approach in Machine Learning Paradigm

This article investigates the classification of normal and COPD subjects on the basis of respiratory sound analysis using machine learning techniques. Thirty COPD and 25 healthy subject data are recorded. Total of 39 lung sound features and 3 spirometry features are extracted and evaluated. Various parametric and nonparametric tests are conducted to evaluate the relevance of extracted features. Classifiers such as support vector machine (SVM), k-nearest neighbor (KNN), logistic regression (LR), decision tree and discriminant analysis (DA) are used to categorize normal and COPD breath sounds. Classification based on spirometry parameters as well as respiratory sound parameters are assessed. Maximum classification accuracy of 83.6% is achieved by the SVM classifier while using the most relevant lung sound parameters i.e. median frequency and linear predictive coefficients. Further, SVM classifier and LR classifier achieved classification accuracy of 100% when relevant lung sound parameters, i.e. median frequency and linear predictive coefficient are combined with the spirometry parameters, i.e. forced vital capacity (FVC) and forced expiratory volume in 1  s (FEV1). It is concluded that combining lung sound based features with spirometry data can improve the accuracy of COPD diagnosis and hence the clinician ’s performance in routine clinical practice. The proposed approach is of great significance in a clinical scenario wherein it can be used to assist clinicians fo...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research

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Conclusions: PG-D2 levels may be a valuable biomarker to differentiate COPD in asthma and ACOS patients. PMID: 31403365 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Spirometry is the current gold standard for diagnosing and monitoring the progression of Chronic Obstructive Pulmonary Disease (COPD). However, many current and former smokers who do not meet established spirometric criteria for the diagnosis of this disease have symptoms and clinical courses similar to those with diagnosed COPD. Large longitudinal observational studies following individuals at risk of developing COPD offer us additional insight into spirometric patterns of disease development and progression.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Review article Source Type: research
Authors: Pavasini R, Fiorencis A, Tonet E, Gaudenzi E, Balla C, Maietti E, Biscaglia S, Papi A, Ferrari R, Contoli M, Campo G Abstract Chronic obstructive pulmonary disease (COPD) is frequently undiagnosed in patients with ischemic heart disease. Nowadays, it is still unknown whether undiagnosed concomitant COPD is related to early structural changes of the heart, as detectable by trans-thoracic echocardiography (TTE). Starting from the study population of the Screening for COPD in ACS Patients (SCAP) trial, we sought to investigate potential differences in echocardiographic parameters in patients with acute corona...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Perturbations in airway mucus properties contribute to lung function decline in patients with chronic obstructive pulmonary disease (COPD). While alterations in bulk mucus rheology have been widely explored, microscopic mucus properties that directly impact on the dynamics of microorganisms and immune cells in the COPD lungs are yet to be investigated. We hypothesised that a tightened mesh structure of spontaneously expectorated mucus (i.e. sputum) would contribute to increased COPD disease severity. Here, we investigated whether the mesh size of COPD sputum, quantified by muco-inert nanoparticle (MIP) diffusion, correlate...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Lung biology and experimental studies Original Articles: Basic science and COPD Source Type: research
no GE Abstract INTRODUCTION: Several studies have previously demonstrated that long-term exposure to outdoor pollution present airway inflammation in term of an increase of sputum neutrophils. AIM AND METHODS: The aim of our study was to evaluate the level of airway inflammation by induced sputum in a group of 15 non-professionally exposed population of well-characterized COPD patients, residing in urban areas with high rate of outdoor pollution, compared to a control group of 13 individuals with COPD, living in rural areas with a low pollution rate. All participants underwent spirometry and sputum induction....
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research
Abstract Chronic obstructive pulmonary disease (COPD) is prevalent in patients infected with HIV. The purpose of this study was to test the hypothesis that systemic oxidation correlates with loss of lung function in subjects with COPD, and that HIV infection can contribute to creating such an environment. Subjects were recruited at the University of Louisville in the following groups: HIV-infected (n = 36), COPD (n = 32), HIV and COPD (n = 28), and uninfected controls with normal lung function (n = 34). HIV infection was assessed by viral load and CD4 cell counts. Pulmonary function was determined ...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
Abstract BACKGROUND: Diffusing capacity of the lung for carbon monoxide (DLCO) is inconsistently obtained in patients with chronic obstructive pulmonary disease (COPD) and the added benefit of DLCO testing beyond more common tools is unknown. OBJECTIVE: To determine whether lower DLCO is associated with increased COPD morbidity independent of spirometry and CT emphysema. METHODS: Data for 1806 COPD participants from the COPDGene 5-year visit were analyzed, including pulmonary function testing, quality of life, symptoms, exercise performance, and exacerbation rates. DLCO % predicted was primarily analyzed...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Conclusions: Airway eosinophilia and airway hyperresponsiveness are complicated with 25 – 50% of COPD that have no symptom and history for asthma. These phenotypes of COPD are closely related to symptom stability and reactivity to glucocortisosteroids. These phenotypes may play key roles for advancement of the management and therapy of this disease.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Pulmonary Disease, Chronic Obstructive;   COPD Exacerbation;   Patient Readmission;   Recurrence Intervention:   Diagnostic Test: Spirometry, Forced Oscillation Technique, Step-counter, sputum and blood samples Sponsor:   University College, London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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