Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins ...

Source: Journal of Hematology and Oncology - June 28, 2019 Category: Hematology Authors: Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Michael Steckel, Ashley L. Eheim, Andrea Haegebarth and Carlo Stresemann Tags: Research Source Type: research