Viruses, Vol. 11, Pages 590: Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease

Viruses, Vol. 11, Pages 590: Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease Viruses doi: 10.3390/v11070590 Authors: Garrison Smith Golden Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. CCHFV is also an emerging virus, with recent outbreaks in Western Europe. CCHFV can infect a large number of wild and domesticated mammalian species and some avian species, however the virus does not cause severe disease in these animals, but can produce viremia. In humans, CCHFV infection can lead to a severe, life-threating disease characterized by hemodynamic instability, hepatic injury and neurological disorders, with a worldwide lethality rate of ~20–30%. The pathogenic mechanisms of CCHF are poorly understood, largely due to the dearth of animal models. However, several important animal models have been recently described, including novel murine models and a non-human primate model. In this review, we examine the current knowledge of CCHF-mediated pathogenesis and describe how animal models are helping elucidate the molecular and cellular determinants of disease. This information should serve as a reference for those interested in CCHFV animal models and their utility for evaluation of medical countermeasures (MCMs) and in the study of pathogenesis.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
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Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
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Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research
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Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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Source: Future Virology - Category: Virology Authors: Source Type: research
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