Oral Ketamine Alleviates Behavioral Despair without Cognitive Impairment in Wistar Rats.
Oral Ketamine Alleviates Behavioral Despair without Cognitive Impairment in Wistar Rats. Behav Brain Res. 2019 Jun 24;:112058 Authors: Ecevitoglu A, Canbeyli R, Unal G Abstract Ketamine is a non-competitive NMDA receptor antagonist used as a major anesthetic agent, especially in children. It has also been shown that at sub-anesthetic concentrations, ketamine has acute antidepressant properties. The rapid-onset nature of this effect makes it a promising alternative for classical antidepressants targeting the monoaminergic system. However, ketamine can lead to various cognitive side effects depending on the user/subject as well as its concentration and administration method, and it is still questionable whether this drug can be utilized as a reliable antidepressant. Here, we test the effects of continuous low dose oral ketamine on behavioral despair and spatial working memory in male Wistar rats. We found that 0.4 mg/day, but not 0.2 mg/day, ketamine in 30 ml juice has an antidepressant effect emerging in just 10 consecutive days as measured by means of forced swim tests without impairing spatial working memory performance in the Y-maze for as long as 30 days. These results suggest that, once clinically optimized, long-term use of low dose oral ketamine can produce antidepressant effects. PMID: 31247234 [PubMed - as supplied by publisher]
Conclusions: This study demonstrates no differences in 6-week clinical or radiographic outcomes between patients undergoing primary TKA on single versus overlapping OR days. These results support the safe practice of overlapping surgical scheduling in high-volume primary TKA centers.Level of Evidence: III. PMID: 31413671 [PubMed - in process]
Authors: Cheng Q, Zhang W, Lu Y, Chen J, Tian H Abstract The present study aimed to investigate and compare the analgesic effect and safety of ropivacaine or levobupivacaine in combined spinal-epidural anesthesia during childbirth and their effects on neonatal Apgar scores, as well as maternal and neonatal vital signs. A total of 615 maternal patients undergoing labor between April 2016 and March 2017 were divided into two groups according to the analgesic used for combined spinal-epidural anesthesia during childbirth: The ropivacaine group (n=318) and the levobupivacaine group (n=297). The onset time of analgesia ...
Authors: Tang Y, Meng J, Zhang X, Li J, Zhou Q Abstract Dexmedetomidine and propofol are commonly used sedative agents in pediatric patients undergoing magnetic resonance imaging (MRI). The present meta-analysis aimed to compare dexmedetomidine with propofol in pediatric patients undergoing MRI using trial sequential analysis (TSA). The PubMed, Cochrane Library and Web of Knowledge databases were systematically searched for entries up to August 2018 for potential randomized controlled trials comparing dexmedetomidine with propofol in pediatric patients undergoing MRI. Data were extracted by two independent authors ...
Condition: β1-adrenergic Antagonist Chronic Treatment , Standardized Noxious Stimulus , General Anesthesia for Any Types of Surgery Intervention: Procedure: standardized noxious stimulus under general anesthesia. Sponsor: Ciusss de L'Est de l'Île de Montréal Not yet recruiting
Thinking of becoming a nurse anesthetist? It’s a good idea—the profession’s been listed among U.S. News &World Report’s “best jobs” consistently since 2016 and it’s the #3 “best health care job” for 2020. Their median salary is $165,000, their unemployment rate is just .4 percent, and the Bureau of Labor Statistics projects 16.2 percent The post How to become a nurse anesthetist appeared first on Johns Hopkins Nursing Magazine.
Dr Mark Corden Funtabulously Frivolous Friday Five 290 It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 290
What impact might an opioid-free anesthesia protocol in cardiac surgery have on post-operative morphine consumption, ICU stay, and outcome?BMC Anesthesiology
Conclusions: In this cohort, death primarily resulted from the underlying neurologic disease and withdrawal of life-sustaining treatment and not from our treatment choices. Use of anesthetic drugs, medical complications, and mechanical ventilation were not associated with in-hospital and 90-day mortality.
Objectives: Airway closure is involved in adverse effects of mechanical ventilation under both general anesthesia and in acute respiratory distress syndrome patients. However, direct evidence and characterization of individual airway closure is lacking. Here, we studied the same individual peripheral airways in intact lungs of anesthetized and mechanically ventilated rabbits, at baseline and following lung injury, using high-resolution synchrotron phase-contrast CT. Design: Laboratory animal investigation. Setting: European synchrotron radiation facility. Subjects: Six New-Zealand White rabbits. Interventions: ...
Playing virtual reality games or relaxing in a virtual nature setting might help ease chronic pain, particularly when symptoms are severe, a new experiment suggests.Reuters Health Information