Underactive bladder in aging rats is associated with a reduced number of serotonin ‐expressing cells in the urethra and is improved by serotonin application to the urethra

AbstractThe aim of this study was to determine whether aging ‐related detrusor underactivity (DU) involves a decrease in 5‐hydroxytryptamine (5‐HT‐positive)‐expressing urethral cells and whether 5‐HT stimulation of urethral sensory fibers improves detrusor function. Cystometries were performed in young (6 months) and aged (18–24 months) female Wistar rats. Aged rats with voiding contractions (VC) that were 2SD below the mean of those in young rats were considered to have DU. Bladder voiding efficiency (BVE) was calculated during saline or 5‐HT solution cystometries. Rats were perfusion‐fixed with a fixative solution (paraformaldehyde , PFA 4%) through the circulatory system and the urethra sectioned to count the number of 5‐HT‐immunoreactive (IR) cells. Isovolumetric cystometry was performed while irrigating the urethra with saline or 5μM‐HT solution. Two‐tailed unpairedt tests were used to determine the significance of differences. In aged DU rats, the mean ( ±SD) VC frequency was 0.24 ± 0.07 per minute, with an amplitude of 15 ± 3 cm H2O. The mean ( ±SD) number of 5‐HT‐IR cells in the urethra of aged DU and young rats was 90 ± 11 and 182 ± 25, respectively (P 
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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