Outcomes of Bladder Preservation Following Treatment for Rhabdomyosarcoma

AbstractPurpose of ReviewGenitourinary rhabdomyosarcoma (RMS) is a relatively uncommon pediatric urologic oncologic condition with significant implications for both short- and long-term bladder functions. It is important for both pediatric and adult urologists to be aware of the pathophysiology, treatment, and long-term prognosis of this tumor and its potential impact on bladder function in both pediatric and adult survivors.Recent FindingsAbnormalities in bladder function may arise secondary to surgical or medical management. Typical presenting complaints include lower urinary tract symptoms, which may be more common in pediatric RMS survivors than in survivors of other childhood cancers. Post-treatment evaluation of urinary function should include a baseline urodynamics study and an assessment of symptom severity and bother using validated, age-appropriate questionnaires. Upper tract monitoring should include renal/bladder ultrasound and serum creatinine. Hemorrhagic cystitis, which often develops acutely in patients receiving alkylating agents, may also present as a late effect. Lastly, urinary diversion may be required in patients with bladder/prostate (BP)-RMS either due to initial or delayed cystectomy or due to radiation-related loss of bladder function. Recent data suggest that diversion can maintain excellent quality of life in these patients.SummaryBoth BP-RMS and its treatments have the potential for profound impacts on long-term bladder function. Most BP-RMS patie...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research

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AM Abstract Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. Definition of key characteristics relevant for effective and specific tumor rejection is essential to improve current TCR-based adoptive T-cell immunotherapies. We here characterized in-depth two TCRs derived from the human leukocyte antigen (HLA)-mismatched allogeneic repertoire targeting two different myel...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Front Immunol Source Type: research
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Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Advances in nanophotonics could one day lead to new treatments for cancer, mental disorders More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298904&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Brigid K. Killelea, Emily J. Gallagher, Sheldon M. Feldman, Elisa Port, Tari King, Susan K. Boolbol, Rebeca Franco, Kezhen Fei, Derek Le Roith, Nina A. BickellAbstractIntroductionAlthough breast cancer incidence is higher among white women, black women are more likely to have aggressive tumors with less favorable histology, and to have a worse prognosis. Obesity and alcohol consumption have been identified as two modifiable risk factors for breast cancer, while physical activity may offer protection. Little however is known abo...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Laura H. Rosenberger, Samantha M. Thomas, Jennifer K. Plichta, Oluwadamilola M. Fayanju, Terry Hyslop, Rachel A. Greenup, E. Shelley HwangAbstractBackgroundSentinel lymph node biopsy has supplanted axillary lymph node dissection (ALND) in clinically node-negative breast cancer and select node-positive disease. We hypothesized a decreasing rate of both ALND and resident exposure over time.MethodsWe identified women with clinical Stage I-III breast cancer in the National Cancer Data Base (2004-2014). Adjusted multivariate logisti...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAmong breast cancer patients, nearly one-third exhibit clinical-pathological stage discordance. This high likelihood of discordance is important to consider for counseling and treatment planning.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
This study assessed the effectiveness and safety of percutaneous mechanical thrombectomy and catheter-directed thrombolysis combined with stent placement in the management of iliac vein compression syndrome with acute iliofemoral deep venous thrombosis (DVT).MethodsFrom December 2014 to April 2016, there were 46 patients with DVT who underwent percutaneous mechanical thrombectomy and catheter-directed thrombolysis and stenting for acute proximal DVT with computed tomography-verified iliofemoral stenosis. The Venous Registry Index was used for evaluating the degree of patency after pharmacomechanical thrombolysis; the preva...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
Publication date: Available online 19 July 2019Source: European Journal of Surgical OncologyAuthor(s): John Tapper, Stefan Arver, Torbjörn Holm, Matteo Bottai, Mikael Machado, Ravi Jasuja, Anna Martling, Christian BuchliAbstractAimThe aim of this study is to analyze postoperative adverse events (AE) in relation to acute primary testicular failure after radiotherapy (RT) for rectal cancer.MethodThis relation was assessed in 104 men, included in a previous prospective cohort study of men treated with surgical resection of the rectum for rectal cancer stage I-III. Postoperative AE were graded according to Clavien-Dindo (...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionExhaled breath condensate analysis combined with MS technique may become a valuable method for lung cancer screening and Dermcidin and S100A9 may serve as biomarkers for lung cancer diagnosis or prognosis.
Source: Lung - Category: Respiratory Medicine Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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