Digoxin in Atrial Fibrillation: An Old Topic Revisited.

Digoxin in Atrial Fibrillation: An Old Topic Revisited. Curr Cardiol Rev. 2019 Jun 18;: Authors: Ferrari F, Rafael Miranda Ferreira Santander I, Stein R Abstract Digoxin has been used for more than 50 years in patients with atrial fibrillation (AF), with the goal of controlling heart rate (HR) and restoring sinus rhythm. In the last two decades, several studies have correlated therapeutic use of digoxin with increased mortality. However, such studies have potential biases that cannot be disregarded, mainly because they are cross-sectional experiments or post-hoc analyses of randomized controlled trials (RCTs). Despite uncertainties regarding the safety of digoxin in this setting, it remains one of the most prescribed drugs for AF worldwide. On the other hand, the absence of any RCTs designed to evaluate mortality makes a definitive conclusion more difficult to reach; therefore, this medication must be used with care. In this review, we explored the therapeutic use of digoxin in the context of AF, discussed mortality data by means of a critical analysis in the light of the best available evidence, and position ourselves in relation to a more rigorous control of serum levels of this drug in daily practice. PMID: 31237216 [PubMed - as supplied by publisher]
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research

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Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
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Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: REVIEW Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: EDITORIAL –INVITED Source Type: research
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