Association of genetic variants in CYP3A4, CYP3A5, CYP2C8, and CYP2C19 with tacrolimus pharmacokinetics in renal transplant recipients.

CONCLUSIONS: Two tagger SNPs, namely, rs15524 and rs4646453, are significantly related to the variability of TAC disposition, and TAC measurement time points, BMI, usage of sirolimus, and incidence of DGF contribute to this influence. Recipients carrying H2/H2 (GG-AA) haplotype in rs15524-rs4646453 may require a low dosage of TAC during 1-year follow-up posttransplant. PMID: 31244435 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31244435?dopt=Abstract

Source: Current Drug Metabolism - June 25, 2019 Category: Drugs & Pharmacology Authors: Wang Z, Zheng M, Yang H, Han Z, Tao J, Chen H, Sun L, Guo M, Wang L, Tan R, Wei JF, Gu M Tags: Curr Drug Metab Source Type: research