Expression of miR-9 and miR-200c, ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran.

In this study, expression levels of miR-200c<br />and miR-9, ZEB-1, ZEB-2 and E-cadherin were assessed in 30 non-small cell lung cancers (NSCLCs) by real-time<br />qPCR. MiR-9 was down-regulated significantly in tumor tissues compared to normal adjacent tissues, while there was<br />no significant change in expression level of miR-200c. On the other hand, ZEB1 demonstrated significant increase<br />and ZEB2a decrease at the mRNA level. These results indicate roles for miR-9 and ZEB1 in genesis of lung cancer,<br />although clinico-pathological associations were not evident. Further studies are necessary to assess implications for<br />treatment of lung cancer. PMID: 31244281 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research