Around the Diabetes Online Community: June 2019
Check out our monthly DiabetesMine roundup of favorite posts from around the Diabetes Online Community for June 2019.
Several omics platforms currently are being used for biomarker discovery. Data integration from multiple platforms while simultaneously accounting for clinical variables is only beginning to be attempted. Kammer and colleagues were interested in identifying prognostic biomarkers for rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. They used a novel Bayesian approach to analyze clinical, proteomic, metabolomic, and lipidomic data from patients whose CKD progressed rapidly or remained stable.
As many as 10% to 20% of patients undergoing kidney transplantation develop post-transplant diabetes mellitus, which is associated with increased mortality. Even borderline changes in glucose metabolism, so-called prediabetes, may involve a similar risk. A recent study by Porrini et al. showed for the first time that such changes in glucose metabolism are in fact associated with future cardiovascular disease and death in kidney-transplanted patients. This commentary discusses the relevance and clinical implications of these new findings.
Authors: Coperchini F, Croce L, Denegri M, Awwad O, Ngnitejeu ST, Magri F, Chiovato L, Rotondi M Abstract Phenformin is a biguanide drug which, besides the original anti-diabetic effect, also exerts anti-cancer effects. The aim of this study was to further characterize these latter in terms of both cell-viability and modulation of the secretion of the pro-tumorigenic chemokine CXCL8. Normal human thyrocytes in primary cultures (NHT) and thyroid cancer cell lines, TPC-1 and 8505C (RET/PTC and BRAFV600E mutated, respectively) were treated with increasing concentrations of phenformin at different times. Cell-viability...
Authors: Geagea AG, Rizzo M, Jurjus A, Cappello F, Leone A, Tomasello G, Gracia C, Kattar SA, Massaad-Massade L, Eid A Abstract [This corrects the article DOI: 10.18632/oncotarget.26641.]. PMID: 31741717 [PubMed - in process]
Publication date: Available online 19 November 2019Source: Journal of Functional FoodsAuthor(s): Lucía Diez-Gutiérrez, Leire San Vicente, Luis Javier R. Barrón, María del Carmen Villarán, María ChávarriAbstractProbiotics have attracted growing interest in recent decades due to their multiple health benefits. The synergistic relationship between probiotics and prebiotics can enhance the production of metabolites called postbiotics, which are gaining increasing importance because of their beneficial functions in the gastrointestinal tract and their influence on different organ...
Conclusions: The core-competence system framework includes six core competencies, which represent the main characteristics of primary nurse specialists in diabetes care who are highly recommended by experts. It is important to keep in mind that this is only a theoretical framework and thus must be further tested in clinical practice settings in China.
Condition: Type2 Diabetes Interventions: Drug: Evogliptin 5mg; Drug: Evogliptin Placebo; Drug: Dapagliflozin 10mg; Drug: Metformin ≥ 1000mg Sponsor: Dong-A ST Co., Ltd. Not yet recruiting
Condition: Diabetic Kidney Disease Interventions: Drug: MEDI3506; Drug: Placebo Sponsor: AstraZeneca Not yet recruiting
The technology proved its merit in a pilot that reported high detection rates and adherence, and is already in use at 15 VA medical centers.
Publication date: Available online 19 November 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Rasmus Kold-Christensen, Mogens JohannsenMethylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes. As the formation of AGEs is nonenzymatic, the damage caused by MG and AGEs has been regarded as unspecific. This may have resulted in the field generally been regarded as unappealing by many researchers, as detailed mechanism...