Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer.

CONCLUSIONS: Tumors from younger and older patients with CRC demonstrated similar overall rates of genomic alteration. However, differences were noted in several genes relevant to biology and response to therapy. Further study will need to be conducted to determine if the differences in gene alteration rates can be leveraged to provide personalized therapies for young patients with early-onset sporadic CRC.
PMID: 31243121 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - June 25, 2019 Category: Cancer & Oncology Authors: Lieu CH, Golemis EA, Serebriiskii IG, Newberg JY, Hemmerich A, Connelly C, Messersmith WA, Eng C, Eckhardt SG, Frampton GM, Cooke M, Meyer JE Tags: Clin Cancer Res Source Type: research