Exposure to Antidepressant Medication and the Risk of Incident Dementia.

CONCLUSION: In this study, monotherapeutic antidepressant exposure in old age was associated with increased incident dementia. Clinicians, caregivers, and patients may wish to consider this potentially negative consequence of antidepressant exposure and aim to balance the costs and benefits of treatment. PMID: 31235427 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

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Conclusion: Interventions directed at the promotion of the QoL of patients with mild AD should focus on the promotion of mindfulness skills in AD patients, in addition to the reduction of psychological morbidity and the promotion of functionality, awareness of the disease, family relationships and social support. PMID: 31411042 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
Purpose of review Physicians treating patients with Parkinson disease must evaluate not only motor symptoms but also acquire expertise in assessing the complex behavioral features that often accompany the disease, such as dementia, apathy, anxiety, and depression. Recent findings There is a risk of diagnostic confusion and error because many of the behavioral and motor symptoms accentuate, overlap, or mimic each other. Summary Awareness of potential diagnostic pitfalls and "pseudo-syndromes" should lead to more accurate clinical assessment and better care for our patients.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Clinical neurology examination, Parkinson's disease/Parkinsonism, All Neuropsychology/Behavior, Parkinson's disease with dementia, Assessment of cognitive disorders/dementia Review Source Type: research
Neuropsychiatric symptoms (NPS) are now recognized as a major component of neurocognitive disorders, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). NPS in dementia, also referred to as behavioral and psychological symptoms of dementia (BPSD), can take various forms, including: psychotic symptoms, mood disturbances (e.g., depressive symptoms and anxiety), and socially inappropriate behaviours.1,2 NPS are highly prevalent in the course of these disorders, with a large cross-sectional study reporting up to 80% of individuals exhibiting a clinically significant neuropsychiatric manifestation after onset of...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
Conclusion: The benefits of this mHealth intervention for carers of people living with dementia were not sustained over a long time. Similarly, other psychosocial interventions for carers of people with dementia rarely reported long-lasting effects. In order to sustainably contribute to carers' well-being, researchers and clinicians should continuously ensure flexible adjustment of the intervention and consider additional features such as ad-hoc counseling options and booster sessions. In this regard, mHealth interventions can offer ideally suited and unique opportunities. PMID: 31368355 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
An intervention to reduce depression and anxiety in people caring for a relative with dementia continues to be clinically effective six years after delivery, new research shows.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. Methods and findingsWe harmonized longitudinal data from 20 population-based cohorts from 15 countries over 5 continents, including 48,522 individuals (58.4% women) aged 54 –105 (mean = 72.7) years and without dementia at baseline. Studies had 2–15 years of follow-up. The risk factors investigated were age, sex, education, alcohol consumption, anxiety, apolipoprotein E ε4 allele (APOE*4) status, atrial fibrillation, blood pressure and pulse pre...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
In this paper, we conduct a literature survey about various virtual reality (VR) treatments in psychiatry. We collect 36 studies that made use of VR to provide clinical trials or therapies for patients with psychiatric disorders. In order to gain a better understanding of the management of pain and stress, we first investigate VR applications for patients to alleviate pain and stress during immersive activities in a virtual environment. Particularly for anxiety, VR exposure therapies are effective in provoking realistic reactions to feared stimuli. On top of that, the exposure therapies with simulated images are beneficial...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract Adenosine is a purine nucleoside, responsible for the regulation of a wide range of physiological and pathophysiological conditions by binding with four G-protein-coupled receptors (GPCRs), namely A1, A2A, A2B and A3 adenosine receptors (ARs). In particular, A1 AR is ubiquitously present, mediating a variety of physiological processes throughout the body, thus represents a promising drug target for the management of various pathological conditions. Agonists of A1 AR are found to be useful for the treatment of atrial arrhythmia, angina, type-2 diabetes, glaucoma, neuropathic pain, epilepsy, depression and ...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Pharm Des Source Type: research
This study investigated the feasibility of a cognitive behavioral therapy (CBT) program for a female patient with mild cognitive impairment (MCI), depression, and anxiety, to improve her mood and quality of life. The program comprised of eight 30-minute weekly sessions with interventions such as behavioral activation, relaxation, and cognitive reconstruction, in which the patient's caregiver also participated. An assessment evaluating the patient's condition were conducted before and immediately after the intervention. After 3 and 12 months, the caregiver reported the patient's behavioral and psychological symptoms using s...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
“In my case, symptoms began to appear when I was only 57. In fact, the doctors believe early-onset Alzheimer’s has a strong genetic predictor, and that it may have been progressing for some years before I was diagnosed.” – Pat Summitt  Anyone who’s gone through the experience of a loved one developing Alzheimer’s disease and progressively deteriorating to a shell of their former selves knows how devastating this brain disease is for both patient and those who love and care for him or her.  Memory Performance Changes May Show Up in 20s with Family History of Alzheimer’s St...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Memory and Perception Alzheimer's disease Dementia Source Type: blogs
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