Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case –control study

ConclusionsIn this study, we report, for the first time, the plasmatic metabolomic profiles of children with ASD, including two different phenotypes based on mental regression status. The use of a liquid chromatography-mass spectrometry platform approach for metabolomics in ASD children using plasma appears to be very efficient and adds further support to previous findings in urine. Furthermore, the present study documents several changes related to amino acid, NAD+ and lipid metabolism that, in some cases, such as arginine and glutamate pathway alterations, seem to be associated with the AR phenotype. Further targeted analyses are needed in a larger cohort to validate the results presented herein.
Source: Metabolomics - Category: Biology Source Type: research

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In this study, we have used a novel DNAzyme based approach to create a larval model of FXS in zebrafish with specific focus on the early developmental window.MethodsFmr1specific DNAzymes were electroporated into embryos to create theknockdown. Changes in RNA and protein levels of FMRP and relevant biomarkers were measured in the 0-7dpf window. Behavioral tests to measure anxiety, cognitive impairments and irritability in the larvae were conducted at the 7dpf stage. Drug treatment was carried out at various time points in the 0-7dpf window to identify the critical window for pharmacological intervention.ResultsThe DNAzyme b...
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
This article was first published in November 2017, ahead of Stars in Our Schools 2017. Rosie is currently campaigning for re-election in the current general election Rosie Duffield is still in shock. It never occurred to her that when she stood as a Labour candidate in the very safe Tory parliamentary seat of Canterbury earlier this year, that she might end up as an MP. The seat had never been held by Labour. But win she did. And she’s taking her new life in her stride – despite working six or seven days a week, staying up to all hours of the night to be present for votes in the House of Commons, and juggling a...
Source: UNISON meat hygiene - Category: Food Science Authors: Tags: Article school support staff schools stars in our schools Source Type: news
Given that many parents of children with autism seek out complementary and alternative therapies, the Canadian Paediatric Society says it's important that doctors get informed and talk about them — especially since those therapies are often expensive, unproven and even potentially harmful.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
We report here the derivation of familial iPSC lines from two controls and three ASD patients carrying NRXN1α+/−, using a non-integrating Sendai viral kit. The genotype and karyotype of the resulting iPSCs were validated by whole genome SNP array. All iPSC lines expressed comparable levels of pluripotency markers and could be differentiated into three germ layers.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
ConclusionsPrevention efforts to reduce ED utilization, especially for those with ID and ASD with co-occurring psychiatric conditions, is warranted. Primary care providers and case managers should develop care plans to reduce the likelihood for emergency psychiatric utilization and ensure alternative care pathways. ED clinicians may require additional training to address the needs of this population when they present to the ED in crisis.
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Successfully navigating social interactions requires the precise and balanced integration of social and environmental cues. When such flexible information integration fails, maladaptive behavioral patterns arise, including excessive aggression, empathy deficits, and social withdrawal, as seen in disorders such as conduct disorder and autism spectrum disorder. One of the main hubs for the context-dependent regulation of behavior is cingulate cortex, specifically anterior cingulate cortex (ACC) and midcingulate cortex (MCC). While volumetric abnormalities of ACC and MCC have been demonstrated in patients, little is known abo...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This article addresses the importance of and challenges associated with costing GS using a GS microcosting project in autism spectrum disorder as an illustrative example.
Source: Journal of Community Genetics - Category: Genetics & Stem Cells Source Type: research
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Source: Journal of Intellectual and Developmental Disability - Category: Disability Authors: Source Type: research
In nature, there are some biological processes that are almost unstoppable. Once the process is started it creates a cascade of reactions and, like a freight train barreling down the track, stopping it takes an immense amount of effort. One of the most classic of these, and perhaps the strongest in human biology, is labor. Once the signals arrive for labor to happen, they build on each other and become relentless. When the contractions start, those strong uterine contractions get stronger and stronger and build and come closer together. There are very few things that can stop contractions. But there are some very powerful ...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Dr. Greene's Blog Uncategorized Bath Time Natural Source Type: blogs
The charismatic llama is a welcome addition at some nursing homes and rehabilitation centers.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Service Dogs and Other Animals Llamas Therapy and Rehabilitation Hospice Care Elderly Nursing Homes Alpacas Elder Care Autism Retirement Communities and Assisted Living Source Type: news
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