New Compound Could Make Chemotherapy More Effective

A research team from the Duke University Medical Center and the Massachusetts Institute of Technology has uncovered a new compound with potential to make chemotherapy more effective in treating various cancers. The small-molecule inhibitor drug — JH-RE-06 — showed an ability to better-sensitize tumors to Cisplatin, the popular chemotherapy drug most often used for mesothelioma cancer patients. When combined with Cisplatin, the drug also showed an ability to prevent those tumor cells from becoming treatment resistant, a common problem with this rare cancer caused by asbestos exposure. The research was done on live mice, along with cultured human and mouse cell lines. The testing showed a prolonged animal survival and an ability to suppress tumor progression. Researchers said they expect to start testing in humans soon. The journal Cell published the findings in June. Co-senior author Michael Hemann, associate professor of biology at MIT, told Medical News Today that the goal of the research was to enhance the power of chemotherapy. “It’s very well established that with these frontline chemotherapies that we use, if they don’t cure you, they make you worse. We’re trying to make the therapy work better,” Hemann said. “We also want to make the tumor recurrently sensitive to therapy upon repeated doses.” Graham Walker, American Cancer Society Research Professor of Biology at MIT, is the other senior co-author of this groundbre...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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CONCLUSIONS: Our study indicated that propofol inhibited A549 cell growth, accelerated apoptosis via the miR-21/PTEN/AKT pathway in vitro, suppressed NSCLC tumor cell growth, and promoted apoptosis in vivo. Our findings provide new implications for propofol in cancer therapy and indicate that propofol is extremely advantageous in surgical treatment. PMID: 32925348 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Publication date: Available online 16 September 2020Source: Molecular and Cellular ProbesAuthor(s): Yaxun Li, Hao Li, Wei Wang, Xiaodong Yu, Qun Xu
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
AbstractMany chemicals found in mangroves reportedly exhibit potent anticancer, antibacterial, anti-inflammatory, antioxidant, and antitumor properties. Several of such compounds include feature unique structures and display interesting pharmacological effects. Few medicinal mangrove plants from Vietnam have been characterized with regard to their chemical constituents.Aegiceras corniculatum (L.) Blanco is a mangrove shrub that exhibits activity against various types of cancer. To identify new secondary metabolites and determine the source(s) of biological activity in Vietnamese medicinal mangrove plants, the chemical cons...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
The annual fundraiser supports art and wellness programs for patients, survivors and caregivers coping with cancer.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Authors: Faghih Z, Taherifard E, Daneshmand A, Talei A, Erfani N PMID: 32921275 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Coumestrol ameliorates doxorubicin-induced cardiotoxicity via activating AMPKα. Free Radic Res. 2020 Sep 13;:1-23 Authors: Wu ZZ, Rao M, Xu S, Hu HY, Tang QZ Abstract Doxorubicin (DOX) acts as the cornerstone in multiple tumor chemotherapy regimens, however, its clinical application is often impeded due to the induction of a severe cardiotoxicity that eventually provokes left ventricular dysfunction and congestive heart failure. Coumestrol (CMT) is a common dietary phytoestrogen with pleiotropic pharmacological effects. The present study aims to investigate the role and mechanism of CMT on DOX-in...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Publication date: Available online 15 September 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yanfeng Xue, Xiaoran Guo, Xinwei Huang, Zongxin Zhu, Minghui Chen, Jiang Chu, Guixian Yang, Qiang Wang, Xiangyang Kong
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Authors: Pan R, Yang X, Shu Z, Gu Y, Weng L, Jia Y, Feng J Abstract OBJECTIVE: To investigate the value of texture analysis in magnetic resonance images for the evaluation of Gleason scores (GS) of prostate cancer. METHODS: Sixty-six prostate cancer patients are retrospective enrolled, which are divided into five groups namely, GS = 6, 3 + 4, 4 + 3, 8 and 9-10 according to postoperative pathological results. Extraction and analysis of texture features in T2-weighted MR imaging defined tumor region based on pathological specimen after operation are performed by texture software OmniKinetics. The valu...
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Evaluation of reconstruction algorithms for a stationary digital breast tomosynthesis system using a carbon nanotube X-ray source array. J Xray Sci Technol. 2020 Sep 10;: Authors: Hu Z, Chen Z, Zhou C, Hong X, Chen J, Zhang Q, Jiang C, Ge Y, Yang Y, Liu X, Zheng H, Li Z, Liang D Abstract Breast cancer is the most frequently diagnosed cancer in women worldwide. Digital breast tomosynthesis (DBT), which is based on limited-angle tomography, was developed to solve tissue overlapping problems associated with traditional breast mammography. However, due to the problems associated with tube movement dur...
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Correction: MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression. Oncotarget. 2020 Aug 25;11(34):3263-3264 Authors: Li C, Song L, Zhang Z, Bai XX, Cui MF, Ma LJ Abstract [This corrects the article DOI: 10.18632/oncotarget.11888.]. PMID: 32922665 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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