HIV-1 Antiretroviral Resistance in Cuba, 2009-2014.
CONCLUSIONS Detected levels of transmitted drug resistance highlight the need for a national surveillance study in treatment-naïve patients. Resistance prevalence is high in previously treated patients but appears to be decreasing over time. The frequency of resistance mutations in recombinant forms of HIV in Cuba needs further study. KEYWORDS Antiretroviral therapy, highly active antiretroviral therapy, HIV, anti-HIV agents, drug resistance, multiple drug resistance, Cuba. PMID: 31242157 [PubMed - in process]
Conclusions: Adherence to ART was higher than to MDR-TB treatment among persons with MDR-TB/HIV coinfection. Missed clinic visits may be a simple measure for identifying patients at risk of unsuccessful MDR-TB treatment outcome.
In conclusion, our screen identified the Hippo signaling pathway as the mediator of regorafenib efficacy in HCC.
Extended-spectrum beta-lactamase- (ESBL-) and AmpC beta-lactamase- (AmpC-) producing Enterobacteriaceae pose a risk for both human and animal health. For livestock, highest prevalences have been reported in broiler chickens, which are therefore considered as a reservoir of multidrug-resistant bacteria. The possibility of transfer to humans either by a close contact to colonized broiler flocks or through contaminated retail meat results in the necessity to develop intervention measures for the entire broiler production chain. In this regard, a basic understanding of the colonization process is mandatory including the determ...
ConclusionThis study describes the main features of the draft genome of S. agnetis 3682, a strain producing the first bacteriocin (agneticin 3682) reported in this species. A second gene cluster encoding a sactipeptide was also found in the bacterial chromosome. Agneticin 3682 shows a new potential application against clinical MRSA isolates.
ConclusionThese data offer novel information for comparative genomic analyses, in order to track transmission dynamics and the epidemiology of the newly emerging high-risk clone ST307.
ConclusionThe draft genome sequence reported herein will lay the foundation for future research for antibiotic resistance mechanisms and pathogenic mechanisms in Klebsiella quasipneumoniae subsp. quasipneumoniae, and also will promote the comparative analysis with genomic features among different sources of clinically important multidrug resistance strains.
ConclusionsFSS increased albumin uptake, P-gp efflux and cell elongation, but this was not attributed to a mechanosensitive mechanism related to primary cilia in PTECs, but likely to microvilli present at the apical membrane.General significance.FSS-induced improvements in biological characteristics and activity in PTECs was not mediated through a primary cilium-related mechanism.
What factors may help identify the deceased transplant donors at risk of carrying multidrug-resistant organisms?American Journal of Transplantation
In March, 2019, The Journal of Infection published our finding1 that live poultry markets (LPMs) is a huge antibiotic resistance gene (ARGs) reservoir, including the plasmid-mediated colistin resistance gene mcr-1, which have been in the human gut for a long time.2 Recently, a novel mobilized mcr-9 in a multidrug-resistant (MDR) Salmonella enterica Serotype Typhimurium isolate was reported.3 The Gram-negative bacteria co-producing mcr genes and carbapenemases limits our choice for treating MDR infections, however, tigecycline has been considered as the last-resort antibiotic.