Resistance Exercise-Induced Hormonal Response Promotes Satellite Cell Proliferation in Untrained Men but not in Women.

Resistance Exercise-Induced Hormonal Response Promotes Satellite Cell Proliferation in Untrained Men but not in Women. Am J Physiol Endocrinol Metab. 2019 Jun 25;: Authors: Luk HY, Levitt DE, Boyett JC, Rojas S, Flader SM, McFarlin BK, Vingren JL Abstract The purpose was to determine the effect of resistance exercise (RE)-induced hormonal changes on satellite cell (SC) myogenic state in response to muscle damage. Untrained men (n=10, 22±3y) and women (n=9, 21±4y) completed 2 sessions of 80 unilateral maximal eccentric knee extensions followed by either an upper body RE protocol (EX) or a 20-min rest (CON). Muscle samples were collected and analyzed for protein content of Pax7, MyoD, myogenin, cyclin D1, p21 before (PRE), 12h, and 24h after the session was completed. Serum testosterone, growth hormone, cortisol, and myoglobin concentrations were analyzed at PRE, post damage, immediately after (IP), 15, 30, and 60 min after the session was completed. Testosterone was significantly (p<0.05) higher immediately after the session in EX versus CON for men. A significant time × gender x condition interaction was found for MyoD with an increase in EX (men) and CON (women) at 12h. A significant time x condition interaction was found for Pax7 with a decrease in EX and increase in CON at 24h. A significant time effect was found for myogenin, p21, and cyclin D1. Myogenin and p21 were increased at 12h and 24h and Cyclin D1 was increased at 1...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research