High BMI, Weight Gain Linked to Lasting Decrease in ALS Risk

THURSDAY, June 27, 2019 -- High body mass index (BMI) and weight gain are associated with a reduced long-term risk for amyotrophic lateral sclerosis (ALS), according to a study published online June 26 in Neurology. Ola Nakken, M.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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This report presents a novel technique termed the pharyngeal clearance maneuver, which uses a modified application of the mechanical insufflation-exsufflation device to mobilize “secretion burden” at the portion of the trachea above the tracheostomy cuff during cuff deflation. Utilization of this strategy may reduce the risk of aspiration, infection, and respiratory compromise for patients with high cervical spinal cord injury in the acute rehabilitation setting. It is of particular benefit for those whose cuffs are being deflated for the first time and who may have large secretion volumes above the cuff. It ca...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Brief Reports Source Type: research
The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer's disease, the α-synuclein associated with Parkinson's disease, and so forth. In recent years researchers have been devoting ever more effort to investigations of a less well known protein aggregate, TDP-43, assoc...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of motor neurons. Genetic factors play a key role in ALS and identifying variants that contribute to ALS susceptibility is an important step towards understanding the etiology of the disease. The frequency of mutations in ALS patients has been extensively investigated in populations of different ethnic origin. To further delineate the genetic architecture of the Hungarian ALS patients, we aimed to detect potentially damaging variants in major and minor ALS genes and in genes related to other neurogenetic disorde...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 14 August 2019Source: Stem Cell ResearchAuthor(s): Monique Bax, Rachelle Balez, Sonia Sanz Muñoz, Dzung Do-Ha, Claire H. Stevens, Tracey Berg, Mauricio e Castro Cabral-da-Silva, Martin Engel, Garth Nicholson, Shu Yang, Ian P. Blair, Lezanne OoiAbstractDermal fibroblasts from a 59 year old male patient with amyotrophic lateral sclerosis (symptomatic at the time of collection), attributed to a mutation in the cyclin F gene (CCNFS621G), were reprogrammed using mRNA and microRNA-delivered OSKM factors to induced pluripotent stem cells (iPSCs). The generated iPSCs were confirmed pluri...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutrition and chronic disease II Source Type: research
Condition:   ALS (Amyotrophic Lateral Sclerosis) Interventions:   Biological: Monthly autologous Treg cells infusions + 3 times per week Interleukin-2 injections;   Other: Monthly placebo infusions + 3 times per week placebo injections Sponsors:   The Methodist Hospital System;   Massachusetts General Hospital;   The Center for Clinical and Translational Sciences (CCTS) Clinical Research Unit at The University of Texas Health Science Center at Houston;   North East Amyotrophic Lateral Sclerosis Consortium Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We present two cases of ALS with PBC to explore the relationship between the two diseases from the immunological and mitochondrial aspects. Further attention should be given to immune-modulating therapy in ALS patients.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Telomere loops (t-loops) are formed at the ends of chromosomes in species ranging from humans to worms, plants, and with genetic manipulation, some yeast. Recent in vitro studies demonstrated that transcription of telomeric DNA leads to highly efficient t-loop formation. It was also shown that both DNA termini are inserted into the preceding DNA to generate a highly stable t-loop junction. Furthermore, some telomeric RNA remains present at the junction, potentially acting as a plug to further protect and stabilize the t-loop. Modeling the loop junction reveals two mechanisms by which the canonical chromosomal replication f...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
INTRODUCTION: Our pilot study tested the feasibility and performance of an eye-controlled power wheelchair for amyotrophic lateral sclerosis (ALS) patients. METHODS: In this prospective pilot study, participants drove the wheelchair three times aro...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
ConclusionsThe DTI study including the tract-of-interest-based analysis showed the same microstructural corticoefferent involvement patterns in PBP patients as in ALS, which supports the hypothesis that PBP is a phenotypical variant of ALS.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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