Future Perspective of Diabetic Animal Models.

Future Perspective of Diabetic Animal Models. Endocr Metab Immune Disord Drug Targets. 2019 Jun 26;: Authors: Pandey S, Dvorakova MC Abstract The need of today's research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. The enormous successes of animal models have already been acclaimed for identifying key genetic factors and environmental factors such as Idd loci and effects of microorganisms including the gut microbiota, respectively. Furthermore, animal models have also helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of quite success, we have acknowledged that many of discovered immunotherapies on animals did not have a significant impact on human. Numbers of animal models were developed in the past to accelerate the drug discovery pipeline. However, due to poor initial screening and assessment on inequivalent animal models, the percentages of drug candidates, who succeed during clinical trials are very low. Therefore, it is essential to bridge the gap between pre-clinical research and clinical trial by validating the existing animal models for consistency. In this review, we have discussed and evaluated the significance of animal models on behalf of published data on PUBMED. Among most popular diabetic animal models, we have selected six animal models (e.g. BioBreeding rat, "LEW IDDM rat", "Nonobese diabetic ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research