Loxapine, an antipsychotic drug, suppresses intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages.

CONCLUSION: Altogether, our data suggested that loxapine might suppress intracellular bacteria through inhibiting of bacterial efflux pumps. In light of its unique activity, loxapine represents a promising lead compound with translational potential for the development of a new antibacterial agent against intracellular bacteria. PMID: 31239204 [PubMed - as supplied by publisher]
Source: Journal of Microbiology, Immunology, and Infection - Category: Microbiology Authors: Tags: J Microbiol Immunol Infect Source Type: research

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ConclusionsWhen applied to orthopedic stainless steel hardware in vitro, solutions of rifampin and vancomycin powder separately or in combination can completely prevent and eliminate biofilm produced by S. aureus.Level of EvidenceII;
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
ConclusionA review of cases reveals robotic hysterectomies as having the largest rate of SSI in the 6 hospitals examined at 1.98% as compared to laparoscopic hysterectomies with an SSI rate of 0.13% over 2 years. Further research is needed to validate these findings over time and geographic location, and examine reasons why robotic surgery may confirm a higher infection rate than laparoscopic in these locations.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: December 2019Source: Microbial Pathogenesis, Volume 137Author(s): Junlei Yin, Zhao Cheng, Yuchen Wu, Qunli He, Jingjing Zhang, Zhanfeng Yang, Shuming Ding, Jizong Li, Dongguang GuoAbstractParatyphoid fever caused by Salmonella Paratyphi A is a serious public health problem in many countries. In order to and develop a live attenuated candidate vaccine of Salmonella Paratyphi A, a Salmonella pathogenicity island 2 (SPI2, approximate 40 kb) deletion mutant of Salmonella Paratyphi A was constructed by lambda Red recombination, then the biological characteristics and protective ability of the Salmonella Para...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: December 2019Source: Microbial Pathogenesis, Volume 137Author(s): Sadeq Abdulridha Gatea Kaabi, Hadeel Kareem MusaferAbstractA minimum lethal dose on mice for five bacterial pathogens were identified with PCR of neonatal septicemia of Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Citrobacter freundii and Moraxella catarrhalis were studied. Bacteriophage preparations active against 10 isolates of E. coli, 10 isolates of K. pneumoniae, 4 isolates of H. influenzae, 3 isolates of P. aeruginosa, 1 isolate of C. freundii and 1 isolate of M. catarrhalis were tested for ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In conclusion, to best of our knowledge these findings are the first report of isolation of 4-bromophenol and Bis (2-ethylhexyl) phthalate from genus Nocardiopsis, thus suggesting that rare actinomycetes are promising source of therapeutically important bioactive metabolites.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionIt is concluded that NIT resistance in the studied NIT-RE. coli isolates was mainly mediated by nfsA and nfsB alterations.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Electron microscopy revealed a world that exists at scales smaller than the wavelength of light. Advancements in this field have allowed scientists to visualize ever more objects and processes, but actually seeing living cells in 3D and within a liqu...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Materials Nanomedicine News Oncology Pathology Radiology microscopy Source Type: blogs
In this study, we found that mortalin significantly inhibited the replication of porcine epidemic diarrhea virus (PEDV) through restricting virus entry. Mechanistically, a biochemical interaction between the carboxyl terminus of mortalin and clathrin heavy chain (CLTC) was been found, and mortalin could induce CLTC degradation through the proteasomal pathway, thereby inhibiting the clathrin-mediated endocytosis of PEDV into host cells. In addition, artificial changes in mortalin expression affected the cell entry of transferrin, further confirming the above results. Finally, we confirmed that this host-mounted antiviral me...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Liquids, Volume 296Author(s): Subramanian Siva, Changzhu Li, Haiying Cui, Lin LinAbstractIsoeugenol is a natural dual antioxidant/prooxidant. In this research, the inclusion complex (IC) of isoeugenol with 2-hydroxypropyl-β-cyclodextrin (HPβCD) was prepared via the ultrasound (US) method. The US assisted isoeugenol/HPβCD-IC was investigated by various characterization techniques such as UV–Vis absorption, fluorescence, powder X-ray diffraction, Fourier transform infrared spectroscopy, thermal gravimetric analysis and differential scanning c...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Last Thursday, CDC finally revised itswarning to the public about the vaping-associated respiratory disease outbreak to state clearly that vaping THC-containing products is playing a major role in the outbreak. It stated that:" The latest national and state findings suggest products containing THC, particularly those obtained off the street or from other informal sources (e.g. friends, family members, illicit dealers), are linked to most of the cases and play a major role in the outbreak. Therefore, CDC recommends that you should not use e-cigarette, or vaping, products that contain THC."In addition, CDC finallyr...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
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