Loxapine, an antipsychotic drug, suppresses intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages.
CONCLUSION: Altogether, our data suggested that loxapine might suppress intracellular bacteria through inhibiting of bacterial efflux pumps. In light of its unique activity, loxapine represents a promising lead compound with translational potential for the development of a new antibacterial agent against intracellular bacteria.
PMID: 31239204 [PubMed - as supplied by publisher]
Source: Journal of Microbiology, Immunology, and Infection - Category: Microbiology Authors: Yang CY, Hsu CY, Fang CS, Shiau CW, Chen CS, Chiu HC Tags: J Microbiol Immunol Infect Source Type: research
More News: Allergy & Immunology | Dysentery | Gastroenteritis | Genetics | Microbiology | Salmonella | Staphylococcus Aureus | Superbugs | Yersinia