IPEM Topical Report: A 2018 IPEM survey of MRI use for external beam radiotherapy treatment planning in the UK.

 The primary barriers reported to MRI implementation in EBRT planning included costs (e.g., lack of a national tariff for planning MRI), lack of MRI access and/or capacity within hospitals. Despite these challenges, significant interest remains in increasing MRI-assisted EBRT planning over the next five years.&#13. PMID: 31239419 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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In this study we evaluate the lesion detection efficacy of18F-DCFPyL PET/CT in patients with BCR and determine the detection efficacy as a function of their PSA value.MethodsA total of 248 consecutive patients were evaluated and underwent scanning with18F-DCFPyL PET/CT for BCR between November 2016 and 2018 in two hospitals in the Netherlands. Patients were examined after radical prostatectomy (52%), external-beam radiation therapy (42%) or brachytherapy (6%). Imaging was performed 120  min after injection of a median dose of 311 MBq18F-DCFPyL.ResultsIn 214 out of 248 PET/CT scans (86.3%), at least one lesion sug...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
o T, Khan R Abstract Radiochromic films have been widely studied for clinical dosimetry in conventional external beam radiation therapy. With an increase in practice of proton therapy, such films are being conveniently used; however, their spectroscopic characterization for this modality is lacking. This work investigated the response of the EBT3 radiochromic films irradiated in a Mevion S250™ clinical proton beam. Dose, dose rate, inter-batch, sensitivity, and linear energy transfer (LET) dependencies of the films were studied. Pieces of the radiochromic films from different batches were irradiated using a ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
Abstract The purpose of this article was to report the treatment effect of image-guided high-dose-rate interstitial brachytherapy boost in the radical radiotherapy for a huge metastatic carcinoma of cervical lymph nodes from an unknown primary site. The patient was a 75-year-old male. A diagnostic biopsy showed metastatic squamous cell carcinoma and the tumour size was 7.5×6.5×11.5cm3 before treatment (N3; AJCC 7th). After external beam radiotherapy with a dose of 60Gy in 30 fractions, the residual tumour (6.2×4.7×6.0cm3) was treated with image-guided high-dose-rate interstitial brachythera...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
AbstractRe-evaluation of the eye lens radio-sensitivity by the ICRP in 2011 resulted in a significant reduction of the threshold for lens opacities from 8  Gy to 0.5 Gy. This has led to an increase in concern for eye lens doses from treatment sites further from the eye than previously considered. The aim of this study was to examine the out-of-field dose far from the field edge and develop an effective method to accurately characterise the constitue nt components of this dose at varying depths. Dose profile scans using a 0.6 cm3 cylindrical ionisation chamber in a motorised water tank were compared with prev...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research
Conclusion: Adjunctive FLT-PET-CT imaging can complement FDG-PET-CT scan in distinguishing post-treatment radiation changes from disease recurrence in thoracic malignancies. These findings support the investigation of FLT-PET-CT in a larger prospective study.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Although encountered rarely, metastatic lesions in thyroid from nonthyroidal primaries need to be excluded while evaluating thyroid lesions.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
In this study, the utility of PET imaging with a αvβ6 integrin ligand was evaluated in patients with non-small cell lung cancer following pulmonary RT. Subjects with NSCLC who had received pulmonary RT within 6 months were recruited. PET imaging of the lungs over 60 minutes was performed after administration of a fluorine-18 radiolabelled 20 amino acid αvβ6-specific peptide ligand, [18F]-FBAA20FMDV2 (IMAFIB; Cancer Research Technologies (CRT) patented). PET-CT scans were co-registered with the RT planning (RTP) scans and segmented to regions corresponding to RT doses of> 40 Gy (excluding tumour), 2...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary II Source Type: research
Conclusions: We conclude, if brain metastases show avid radioiodine uptake, RAI therapy should be offered before EBRT or surgery.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Therapy Concepts I: Endocrinology Source Type: research
592Objectives: 18F-rhPSMA-7 is a new theranostic PSMA-targeting agent which allows fast radiolabeling with 18F and radiometals. This retrospective analysis investigates the efficacy of 18F-rhPSMA-7 PET/computed tomography (CT) in patients with biochemical recurrence of prostate cancer following curative-intent primary treatment with external beam radiotherapy (EBRT) or brachytherapy. Methods: Datasets from patients with non-castrate biochemical recurrence of prostate cancer after treatment with EBRT or brachytherapy who underwent 18F-rhPSMA-7 PET/CT at either the Technical University Munich or Ludwig-Maximillian University...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Diagnosis I Source Type: research
608Objectives: Co-administration of additional therapies, such as external beam radiation, with checkpoint immunotherapy may result in modulation of checkpoint molecule expression. This process is highly dynamic and difficult to capture with traditional biopsy-based analysis; therefore, molecular imaging, particularly positron emission tomography, may enable real-time insight into these expression levels. The human/mouse cross-reactive anti-PD-L1 antibody atezolizumab was utilized to visualize tumor PD-L1 expression changes following various external beam radiotherapy interventions. Methods: A humanized anti-PD-L1 antibody...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology II Source Type: research
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