ARB Concerns Continue as Macleods Pulls Contaminated Losartan ARB Concerns Continue as Macleods Pulls Contaminated Losartan

The recall comes amid renewed concerns after a recent expanded recall and the discovery of a fourth potential carcinogen in another commonly used hypertension and heart failure medication.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news

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The current SARS-CoV-2 pandemic has high fatality rates and imposes increasingly severe social and economic impacts worldwide. Covid-19 patients with cardiovascular disease are at increased risk of death. They are very often treated with drugs targeting the renin-angiotensin-aldosterone system, where angiotensin converting enzyme (ACE) is of particularly importance. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) are standard therapies for high blood pressure and heart failure (HF) and currently prescribed to more than 25 Mio people in Germany alone (approx.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research
This report reviews our basic studies and clinical trials using curcumin therapeutically to prevent heart failure, as well as the possibility of clinical applications of curcumin. PMID: 32238626 [PubMed - in process]
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Resumo A s índrome da fístula artério-portal (FAP) é uma rara e reversível causa de hipertensão portal pré-sinusoidal, ocasionada pela comunicação de uma artéria visceral com o sistema venoso portal. A maioria dos pacientes é assintomática, mas quando desenvolvem sintomas, estes são mais relaciona dos com sangramento gastrointestinal, ascite, insuficiência cardíaca congestiva e diarreia. Este desafio terapêutico apresenta um caso de FAP decorrente de ferimento antigo por arma branca e subsequente evoluç&atil...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Conclusion: MHR is significantly associated with CVD in COPD patients. Further prospective studies are warranted to elucidate the predictive value of MHR in COPD patients.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Objective: To assess the prognostic value of electrocardiographic atrial fibrillation in older hypertensive people in the randomized, placebo-controlled Hypertension in the Very Elderly Trial. Methods: Hypertension in the Very Elderly Trial randomized 3845 hypertensive people aged 80 years and over, 3273 with electrographic data on the presence or absence of atrial fibrillation at baseline and without established cardiovascular disease. Multivariate Cox proportional hazard models were used to estimate hazard ratios with 95% confidence intervals (CIs) for all-cause mortality, incident fatal and nonfatal major cardiovas...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Risk factors Source Type: research
Based on reports from China, we know that most COVID-19 patients (about 80%) will develop mild flulike symptoms, including fever, dry cough, and body aches that can be managed at home. 20% will develop more serious symptoms, such as pneumonia requiring hospitalization, with about a quarter of these requiring ICU-level care. Initial reports focused on the respiratory effects of COVID-19, such as pneumonia and difficulty breathing. But more recent literature has described serious cardiovascular complications occurring in about 10% to 20% of hospitalized patients. Someone with pre-existing heart disease who becomes ill with C...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Heart Health Hypertension and Stroke Infectious diseases Source Type: blogs
This article will provide a comprehensive review and update on this important disease state.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Authors: Dąbrowska E, Harazny JM, Miszkowska-Nagórna E, Stefański A, Graff B, Kunicka K, Świerblewska E, Rojek A, Szyndler A, Wolf J, Gruchała M, Schmieder RE, Narkiewicz K Abstract Purpose: In the course of hypertension, left ventricular hypertrophy and diastolic dysfunction develop very often and may progress toward heart failure. The aim of the study was to analyze the relationship between abnormalities of retinal microcirculation and cardiac damage defined as left ventricular hypertrophy and/or diastolic dysfunction.Materials and methods: The study comprised 88 patients with essential hypertension. T...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
This study is a cross-sectional study. It will recruit 600 patients with essential hypertension in the outpatient and inpatient department of cardiovascular medicine of Chengdu Fifth People's Hospital. Researchers will obtain blood and urine samples with the patient's informed consent. In addition, we will measure patient's blood pressure and target organ-related information. Trial registry: The study protocol was approved by the Chengdu Fifth People's Hospital. Written informed consent will be obtained from all the participants. The trial was registered in the Chinese Clinical trial registry, ChiCTR2000029243. This tri...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organized thrombi in the pulmonary arteries leading to right heart failure and death. Impaired angiogenesis and systemic inflammation could be involved in the pathophysiology of this disease. The aim of this study was to determine the angiogenic expression profile in patients with CTEPH.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (51) Source Type: research
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