Multivariate Approaches to Understanding Aphasia and its Neural Substrates

AbstractPurpose of ReviewAphasia is often characterized in terms of subtype and severity, yet these constructs have limited explanatory power, because aphasia is inherently multifactorial both in its neural substrates and in its symptomatology. The purpose of this review is to survey current and emerging multivariate approaches to understanding aphasia.Recent FindingsTechniques such as factor analysis and principal component analysis have been used to define latent underlying factors that can account for performance on batteries of speech and language tests, and for characteristics of spontaneous speech production. Multivariate lesion-symptom mapping has been shown to outperform univariate approaches to lesion-symptom mapping for identifying brain regions where damage is associated with specific speech and language deficits. It is increasingly clear that structural damage results in functional changes in wider neural networks, which mediate speech and language outcomes.SummaryMultivariate statistical approaches are essential for understanding the complex relationships between the neural substrates of aphasia, and resultant profiles of speech and language function.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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Photo provided by Avi Golden Avi Golden is an EMT who can no longer talk after suffering a stroke. He now makes it his mission to educate others about those dealing with aphasia.   Editor’s Introduction It was a chance encounter one day as I scanned Facebook posts from “friends” and acquaintances. I have countless “friends”, many of which I have never met in person, but find, through their content or other “friends” to be in my world of interest and specialization. Several postings were from paramedic Avi Golden, one such “friend” I followed frequently on Facebook ...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Training Exclusive Articles Patient Care Source Type: news
Source: International Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Source Type: research
CONCLUSION: Psychosocial well-being improved during the first 6 months after stroke in both arms of the trial, but no statistically significant benefit of the dialogue-based intervention was found compared with usual care. PMID: 31411337 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
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Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Abstract Many patients who meet core/root criteria for Primary Progressive Aphasia (PPA) are not classifiable as a recognized variant and are often excluded from neuroimaging studies. Here, we detail neurological, neuropsychological, speech and language assessments, and anatomic and molecular neuroimaging (MRI, PiB-PET, and FDG-PET) for fifteen (8 female) clinically unclassifiable PPA patients. Median age of onset was 64 years old with median 3 years disease duration at exam. Three patients were amyloid positive on PiB-PET. 14/15 patients had abnormal FDG-PETs with left predominant hypometabolism, affecting fr...
Source: Brain and Language - Category: Neurology Authors: Tags: Brain Lang Source Type: research
Authors: Nishida H, Hayashi Y, Ban Y, Kudo T, Harada N, Sakurai T Abstract A 61-year-old dextral woman was admitted to the hospital with difficulty finding words. Neurological examinations confirmed that her speech was affected by frequent pauses and occasional phonological paraphasia without cognitive deficits. We detected atrophy, hypoperfusion, and hypometabolism in the right perisylvian and parietal regions, expanding to the right anterior temporal lobes and right inferior frontal gyrus (opercular region) by magnetic resonance imaging, single-photon emission computed tomography, and fluorodexyglucose-positron e...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Clinical Rehabilitation - Category: Rehabilitation Authors: Tags: Clin Rehabil Source Type: research
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Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: September 2019Source: The Lancet Neurology, Volume 18, Issue 9Author(s): Agnes Flöel
Source: The Lancet Neurology - Category: Neurology Source Type: research
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