Experimental validation of biocompatible nanostructured lipid carriers of sophorolipid: Optimization, characterization and in-vitro evaluation

In this report, for the first time, lipid nanostructures coated with polysorbates (Tweens) were formulated by a hot dispersion method. By varying the amount of lipid, type of surfactant, and alcohol, dilution ratio etc., the formulation was optimized with respect to its stability, which is a central aspect of their potential applications. Their comprehensive physicochemical characterization was done using static and dynamic light scattering (SLS, DLS), small angle neutron scattering (SANS), zeta-potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM) techniques. Further hemolysis study was conducted to understand the in-vitro cytotoxicity levels of the lipidic nanoparticles prior to its application as a potent drug delivery device for countermanding the problems associated with challenging tuberculosis and leprosy drug-Rifampicin. Attaining high entrapment efficiency and sustained release from the developed carrier, further interaction with bovine serum albumin was investigated, to understand the in-vivo behavior of the nanostructured lipid carriers (NLCs).Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research

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Conclusion The present study showed that high plasma glucose levels and severe liver fibrosis stage influence insulin secretion levels in Japanese patients with NAFLD. Conservation of delayed insulin secretion levels was confirmed in patients with severe liver fibrosis. PMID: 31534089 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: Our study first implied that the A variant of rs17687727 in TGFBRAP1 influenced the susceptibility to ATDILI in first-line antituberculosis combination treatment in the Han Chinese population in a dependent manner. PMID: 31534460 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 19 September 2019Source: Carbohydrate PolymersAuthor(s): Isabel Romo, Lilian Abugoch, Cristian TapiaAbstractThe research aim was to study the nature of intermolecular interactions involved in the formation of soluble complexes between chenopodins (QP) and anionic/cationic polysaccharides, sodium alginate (Alg) and chitosan (CH), above the pI of QP at different protein-polysaccharide ratios; and to evaluate their structural-physicochemical properties. The interactions and properties analysed by electrical conductivity, zeta potential, hydrodynamic particle size, intrinsic and extrinsic flu...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 September 2019Source: Carbohydrate PolymersAuthor(s): Gemma Leone, Marco Consumi, Simone Pepi, Alessio Pardini, Claudia Bonechi, Gabriella Tamasi, Alessandro Donati, Stefania Lamponi, Claudio Rossi, Agnese MagnaniAbstractViscosupplementation, i.e. intra-articular injection of hyaluronic acid derivatives, is considered as the most effective treatment for patients with mild to moderate osteoarthritis. Even if hyaluronic acid is still considered as the gold standard, research is now focusing on the development of new products with enhanced injectability and yet reasonable viscoelastic beh...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 September 2019Source: Thermochimica ActaAuthor(s): Klaudia Ordon, Monika Szlachta, Piotr Szatkowski, Kinga PielichowskaAbstractNew polyurethane-based materials (PUs) have been fabricated via a two-step bulk polymerization method with starch as a crosslinker, and 1,4-butanediol as a chain extender. Hydroxyapatite (HAp) was used as a bioactive compound. The structure, morphology and thermal properties of the PUs were investigated. The chemical structure of the obtained materials was confirmed by FTIR. The SEM-EDX analysis confirmed the incorporation of starch and HAp into the PU matrix. ...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2019Source: PolymerAuthor(s): Khushbu, Sudhir G. Warkar, Anil KumarAbstractThe novel superabsorbent hydrogels (SAH) were fabricated by interpenetrating carboxymethyl tamarind kernel gum with sodium-acrylate. The synthesis of SAH was verified by characterization using Fourier-transform infrared spectroscopy, thermo-gravimetric analysis, scanning electron microscopy and swelling studies under various solutions. The hydrogel formed was found out to be degradable (soil burial biodegradation test). Maximum water holding capacity, bulk density, porosity and water retention capacity...
Source: Polymer - Category: Chemistry Source Type: research
Publication date: October 2019Source: Journal of Environmental Chemical Engineering, Volume 7, Issue 5Author(s): Victor V.C. Lima, Fabíola B. Dalla Nora, Enrique C. Peres, Glaydson S. Reis, Éder C. Lima, Marcos L.S. Oliveira, Guilherme L. DottoAbstractThe biopolymers chitin (CTN) and chitosan (CTS) were functionalized with APTES (3–aminopropyltriethoxysilane) in order to enhance its adsorption potential for sunset yellow dye (SYD). The functionalization was proved by several techniques like FTIR (Fourier transform infrared spectroscopy), XRD (X–ray diffraction), N2 adsorption/desorption isotherms,...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2019Source: Journal of Alloys and CompoundsAuthor(s): J. Belo, S.C. Marques, A.V. Castilho, L.M. de Oliveira, R.A. Simão, D.S. dos SantosAbstractThe Equimolar Fe20Mn20Ni20Co20Cr20 and non-equimolar, Fe22Mn40Ni30Co6Cr2, high-entropy alloys were synthesized and characterized in the present work. Cold rolled and heat-treated samples were studied via scanning electron microscopy, SEM, atomic force microscopy, AFM and X-ray diffraction, XRD. The equimolar alloy was submitted to severe plastic deformation by high-pressure torsion, HPT. Hydrogen permeation of both alloys unde...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2019Source: Journal of Alloys and CompoundsAuthor(s): Wei Tan, Yuan-e Yang, Yan-xiong FangAbstractTo seek bulk Mg-based alloys with excellence H2 production properties, smelted eutectic Mg–Ni-based alloys are successfully prepared by metallurgical method. The phase compositions and microstructures are tested by X-ray diffraction (XRD) and scanning electron microscope (SEM). The isothermal H2 production curves of prepared alloys in 3.5 wt% NaCl solution are collected at different temperatures by drainage method. H2 production kinetics and thermodynamics are investigate...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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