Ergosterols from Ganoderma sinense and their anti-inflammatory activities by inhibiting NO production

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Ren-Qiang Mei, Feng-Jiao Zuo, Xiao-Yan Duan, Yi-Na Wang, Jun-Rong Li, Cheng-Zhen Qian, Ji-Ping XiaoAbstractThree new ergosterols, ganocalidophins A–C (1‒3), along with four known ones, were isolated from the fruiting bodies of Ganoderma sinense. Their structures were established on the basis of extensive NMR and MS technologies, as well as the single crystal X-ray diffraction. Compounds 1‒3 and 6 exhibited inhibitory activities against NO production with IC50 of 17.7–32.4 μM.Graphical abstract

Source: Phytochemistry Letters - June 27, 2019 Category: Chemistry Source Type: research