Shortage of isosorbide mononitrate 10mg, 20mg and 40mg tablets
Source: Department of Health (DH) Area: News The Department of Health has issued a letter highlighting a current shortage of all normal release isosorbide mononitrate presentations (10, 20 and 40mg tablets) because of problems with the availability of raw materials. The shortage of this medicine may last for several months and current information indicates that normal supply is unlikely to resume before the end of April 2013. However, the situation may change from week to week, as it is understood that some companies may obtain some stock before that time, while others are importing unlicensed isosorbide mononitrate for use on an individual patient basis. In the absence of normal release isosorbide mononitrate tablets being available, clinicians are advised to consider substitution with a slow release mononitrate preparation (which are not affected by this supply problem). Limited data exist regarding switching from normal release to modified release tablets but initially a mg per mg substitution would ...
Publication date: Available online 1 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Florina Zakany, Tamas Kovacs, Gyorgy Panyi, Zoltan Varga
CONCLUSION: Pregnancy outcomes after hysteroscopic placement of a microinsert for hydrosalpinx management before embryo transfer were comparable to those following laparoscopic proximal tubal occlusion or salpingectomy. However, caution is advised regarding microinsert placement for hydrosalpinges before proceeding with assisted reproductive technology. PMID: 32224160 [PubMed - as supplied by publisher]
Authors: Feres M, Retamal-Valdes B, Faveri M, Duarte P, Shibli J, Soares GMS, Miranda T, Teles F, Goodson M, Hasturk H, Van Dyke T, Ehmke B, Eickholz P, Schlagenhauf U, Meyle J, Koch R, Kocher T, Hoffmann T, Kim TS, Kaner D, Figueiredo LC, Doyle H Abstract OBJECTIVE: The selection of proper outcome measures is a critical step in clinical research. Most randomized clinical trials (RCTs) assessing the effects of initial anti-infective periodontal therapies use surrogate outcomes as primary outcome variables, such as mean changes in probing depth (PD) or in clinical attachment. However, these parameters do not reflect...
CONCLUSION: Within the limits of our study, the results of this trial indicate that reconstructive periodontal surgery with PTG offers minimal radiographic defect resolution with no significant improvements in clinical endpoints compared to open flap debridement. PMID: 32224548 [PubMed - in process]
CONCLUSION: P. gingivalis and F. nucleatum inoculation induced significant changes in intestinal inflammation and caecal microbiome. Oral gavage with LGG exerted a protective effect against intestinal inflammation and limited gut microbiome changes associated with P. gingivalis and F. nucleatum. PMID: 32224547 [PubMed - in process]
CONCLUSIONS: Non-surgical periodontal therapy was effective during the first 18 months, but periodontal conditions were worse at 48 months after therapy. The distal sites of abutment teeth with direct retainers presented the worst periodontal conditions. PMID: 32224546 [PubMed - in process]
CONCLUSION: Individuals with DD undergoing PMT presented higher rates of recurrence of periodontitis and tooth loss when compared to individuals without DD. Additionally, the interaction between DD and smoking significantly increased the risk for the recurrence of periodontitis. PMID: 32224545 [PubMed - in process]
Publication date: Available online 31 March 2020Source: Contemporary Educational PsychologyAuthor(s): Eike Wille, Gundula Stoll, Thomas Gfrörer, Jenna Cambria, Benjamin Nagengast, Ulrich Trautwein
Publication date: Available online 31 March 2020Source: Food Quality and PreferenceAuthor(s): Andrijana Mušura Gabor, Bojan Stojnić, David Ban-Ostić
Publication date: Available online 31 March 2020Source: Food Quality and PreferenceAuthor(s): Berta Schnettler, Edgardo Miranda-Zapata, Ligia Orellana, Tino Bech-Larsen, Klaus G. Grunert