Hepato–Renal Protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

Publication date: Available online 27 June 2019Source: Toxicology ReportsAuthor(s): Mohamed SeifAbstractThe study was designed to clarify the hapato-nephroprotective effects of purslane ethanolic extract (PEE) against cadmium toxicity. Cadmium (Cd) is a toxic heavy metal. Cd occurs as environmental and food/ feed contamination causing public and animals health hazards. Liver and kidney are the main target organs for acute and chronic cadmium toxicity. Portulaca oleracea is rich in several vitamins, minerals, antioxidant components, and omega-3 fatty acids mainly α-linolenic acid and eicosapentaenoic acid. Results showed significant elevation of the liver and kidney functions, lipid profile and lipid peroxidation. In contrast to the antioxidants enzymatic were greatly decreased. The hepatic and renal tissues showed severe degeneration and necrosis accompanied by severe congestion and multifocal hemorrhages in Cd intoxicated rats. All parameters and tissues showed no changes in rates-treated with both Cd and purslane extract as compared with the control rats. The administration of PEE provided a signi´Čücantly protection against Cd-induced hepato-nephrotoxicity.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research

Related Links:

ConclusionsThe use of adhesive can improve masticatory performance of new complete dentures users with normal mandibular ridges in the initial adaptation period up to 60 days after insertion. For resorbed ridges subjects, the use of adhesive had a negative impact on masticatory discomfort/disability OHRQoL at 30 days after insertion.
Source: Journal of Prosthodontic Research - Category: Dentistry Source Type: research
ConclusionEATP lowered the serum uric acid level and increased the urine uric acid level through excretion, which is useful in the treatment of gout. Hence the EATP was found to be helpful in the treatment of gout.
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 21 August 2019Source: Journal of Ginseng ResearchAuthor(s): Moon Young Park, Se Jik Han, Donggerami Moon, Sangwoo Kwon, Jin-Woo Lee, Kyung Sook KimAbstractBackgroundRed ginseng contains components that can be used in skincare to delay the aging process, including microelements, vitamins, essential oils, and fatty acids. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis.MethodsHuman dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using at...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
ConclusionDifferentially expressed in tumors, PLA2G4A, PRKCB, PIK3R1, KDR, PLA2G1B and PTGS2 are potential therapeutic targets of Yupingfengsan in the treatment of LAD, and MAPK, VEGF and ErbB signaling pathways are involved.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Cardiology CasesAuthor(s): Shohei Kataoka, Ken Kato, Hiroyuki Tanaka, Tamotsu TejimaAbstractIt is challenging to perform ablation of ventricular tachycardia (VT) from the left ventricle (LV) in patients without catheter access to the LV. A 50-year-old man was referred to our hospital for VT. He underwent mechanical aortic and mitral valve replacement for infective endocarditis and embolic myocardial infarction in the left ventricular inferior wall during a surgery. Anti-arrhythmia drugs (AADs) such as sotalol and bisoprolol were initiated and implantable c...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Cardiology CasesAuthor(s): Takashi Ando, Hiroshi Okada, Makoto Takeda, Tomio UmemotoAbstractPeriaortitis is one of the less common manifestations of the aorta pathology. Periaortitis mostly arises from the outer layers of the abdominal aorta and iliac arteries. However, other large arteries may also be involved, but rarely the thoracic aorta. Here we present a successful conservative treatment using prednisolone therapy for periaortitis of the aortic arch which shows various clinical symptoms.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s): Julian Yeoh, Jonathan Hill
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s): David A. Power, Paul Guedeney, George D. Dangas
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s):
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s):
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
More News: Antidoxidants | Egypt Health | Environmental Health | Liver | Minerals | Omega 3 | Study | Toxicology | Urology & Nephrology | Vitamins