N-acetylcysteine dual and antagonistic effect on cadmium cytotoxicity in human leukemia cells

In conclusion, NAC exhibits dual and antagonistic effects on Cd2+ cytotoxicity in human leukemia cells.Graphical Abstract
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their association with inflammation, autoimmune diseases, and cancer. Since the information regarding the role of NKT-like cells in CML is rare, we aimed at the characterization of these cells in CML patients treated with TKIs. Peripheral blood NKT-like cells from 48 CML patients and 40 healthy donors were analyzed by mult...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsCompleting treatment signalled a significant improvement in HRQoL for patients compared to being on treatment. Overall, however, HRQoL was still significantly lower than the population during the early post-treatment period.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Condition:   Leukemia, Myeloid, Acute Intervention:   Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
MONDAY, Oct. 21, 2019 -- For adult survivors of childhood acute lymphoblastic leukemia (ALL), exercise intolerance is associated with worse neurocognitive outcomes, according to a study published online Oct. 21 in Cancer. Nicholas S. Phillips, M.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
MONDAY, Oct. 21, 2019 -- Boosting exercise capacity may protect the mental functioning of childhood leukemia survivors, according to a new study. Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Due to their disease and...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The aim of this study is to develop a prognostic nomogram for early stage extranodal NK/T-cell lymphoma, nasal-type (ENKL) treated with high-dose radiotherapy (RT). A total of 81 patients at two cancer centers with stage I to IIE ENKL who received chemotherapy (CT) and high-dose RT were retrospectively analyzed. The 5-year OS rate and PFS were 64.7% and 57.5% respectively for the entire group. The development of the nomogram was based on the Cox proportional hazards model. We have implemented the concordance index (C-index) and performed a calibration curve to determine its predictive and discriminatory capacity and compar...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
informCLL is the first US-based registry of patients with CLL that initiated enrollment after approval of novel-targeted agents. Prognostic/predictive testing rates and CLL treatment selection, with availability of novel agents, in clinical practice has not been previously investigated. Results from this interim analysis demonstrate that prognostic/predictive testing was infrequently used to guide treatment selection, potentially inhibiting beneficial outcomes for patients.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
We reported on a 54-year-old patient with a diagnosis of grade 2 follicular lymphoma (FL) and concomitant renal cancer. After the nephrectomy, the patient underwent two lines of chemoimmunotherapy, autologous stem cell transplant, obtained a complete response with idelalisib and underwent an allogeneic transplant (alloSCT).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Hepatosplenic T-cell Lymphoma (HSTCL) is a rare peripheral T-cell lymphoma that disproportionately affects individuals with a clinical history of immunosuppression. It carries a poor prognosis, and due to its rarity, there is no single or well-established treatment.We conducted the largest-to-date individual-level meta-analysis based on literature searches to determine the best induction therapy for HSTCL. We compared response rates and survival among patients who received “non-CHOP-based” induction with regimens containing cytarabine, etoposide, and/or platinum-based treatment to those receiving treatment with...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Myelodysplastic syndromes (MDS) mostly affect elderly patients with a median age at diagnosis of 74 years [1 –3]. The International Prognosis Scoring System (IPSS) prognostic classification reflects the heterogeneous clinical course of MDS and may be used to guide therapeutic decisions [4]. Supportive care with transfusions and erythropoietin stimulating agents may compensate cytopenia in patients with l ow risk disease. On the other hand, the treatment of high risk MDS aims at postponing its progression to acute leukemia, e.g.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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