Ghrelin attenuates sepsis-induced acute lung injury by inhibiting the NF- κB, iNOS, and Akt signaling in alveolar macrophages.

In conclusion, ghrelin exerts a protective role against sepsis-induced ALI probably by reducing the production of inflammatory cytokines from AMs via inhibition of NF-κB-iNOS pathway or Akt signaling.
PMID: 31242025 [PubMed - as supplied by publisher]

Source: Am J Physiol Lung Ce... - June 25, 2019 Category: Respiratory Medicine Authors: Zheng H, Liang W, He W, Huang C, Chen Q, Yi H, Long L, Deng Y, Zeng M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research