Pharmacokinetic study of imrecoxib in patients with renal insufficiency

ConclusionThe exposure of imrecoxib in OA patients with renal insufficiency showed a decline compared to that in healthy subjects. However, in patients with renal insufficiency the exposure of M2 was markedly increased and the CL was noticeably reduced. These results indicate that the dosage of imrecoxib should be reduced appropriately in patients with renal insufficiency.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research